![Professor Anne Kiltie Professor Anne Kiltie](/img/200x200/staffpages/uploads/s03ak1/avatar/p7BCQfAeEtKAoM2ZOkxiWhQaMFIA9SeQGKnOC1A7.png)
MA DM DSc MRCP(UK) FRCR
Friends of ANCHOR Clinical Chair in Oncology
- About
-
- Email Address
- anne.kiltie@abdn.ac.uk
- Office Address
Room 5.053
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.
I took up my appointment as Friends of ANCHOR Clinical Chair of Oncology at the University of Aberdeen in June 2021.
My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.
Qualifications
- DSc Medical Sciences2016 - University of Oxford
- DM Medical Sciences1999 - University of Oxford
- BM BCh Medicine1988 - University of Oxford
- BA Medical Sciences1985 - University of Cambridge
- MRCP(UK) General Medicine1992 - Royal College of Physicians of England
- FRCR Clinical Oncology1995 - Royal College of Radiologists
- MA Medicine1989 - University of Cambridge
- MA Medicine1999 - University of Oxford
Memberships and Affiliations
- Internal Memberships
-
Jul 2021 - present Member of the Rowett Institute Ethics Panel
Oct 2021 - present Member of Friends of ANCHOR Research Advisory Group
- External Memberships
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Apr 2024 - present Chair, Scottish Radiation Research Forum (ScoRRF)
Jun 2023 - present Member of RAIDER TrialTranslational Working Group
Jan 2022 - present Member of Scientific Review Group BCAN Bladder Cancer Research Innovation Award 2022
Jan 2022 - present Member of Scottish Radiotherapy Research Forum Committee
Oct 2018 - present Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Research Network Management Committee
Dec 2017 - present Member of Editorial Board of European Urology Oncology
Oct 2016 - present Associate Editor of Bladder Cancer
2014 - present Grant reviewer for Italian Association for Cancer Research (AIRC)
Sept 2012 - present British Uro-oncology Group Executive Committee Trustee
Jan 2012 - present Royal College of Radiologists representative on Advisory Appointments Committees
- Research
-
Research Overview
Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.
Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.
Research Areas
Applied Health Sciences
Biomedical Sciences
Nutrition and Health
Research Specialisms
- Medicine
- Food Science
- Bacteriology
- Oncology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Supervision
Supervisees
- MS MEREL VAN DEN HAAK
- MR ADAM POTTER
- MR DANIEL SESCU
- MISS ANAM WAJID
- Teaching
-
Teaching Responsibilities
ME3013 MBChB SSC2: supervisor
BM4501 BSc Honours project: supervisor
RN5504 Nutrition and Health through the Life Stages: lecture
RN5505 Clinical Nutrition: lecture and seminar
RN5503 Clinical Nutrition for Disease Prevention: lecture
Non-course Teaching Responsibilities
I am a Regent for the MB ChB Regent Scheme.
- Publications
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Page 1 of 1 Results 1 to 96 of 96
Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity
Microbiome, vol. 12, no. 1, 89Contributions to Journals: ArticlesHow do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?
BMJ Oncology, vol. 2, no. 1, e000107Contributions to Journals: Review articlesField-cycling imaging in ovarian cancer: a novel technology
International Journal of Gynecological Cancer, vol. 33, no. 8, pp. 1329-1330Contributions to Journals: Comments and DebatesGenome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights
European Urology, vol. 84, no. 1, pp. 127-137Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2023.04.020
- [ONLINE] View publication in Scopus
Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients
British Journal of Cancer, vol. 127, pp. 2087–2098Contributions to Journals: Review articlesImmunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells
STAR Protocols, vol. 2, no. 4, 100978Contributions to Journals: ArticlesThe role of dietary supplements, including biotics, glutamine, polyunsaturated fatty acids and polyphenols, in reducing gastrointestinal side effects in patients undergoing pelvic radiotherapy: A systematic review and meta-analysis
Clinical and Translational Radiation Oncology, vol. 29, pp. 11-19Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ctro.2021.04.006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16677/1/Bartsch_etal_the_role_of_VOR.pdf
- [ONLINE] View publication in Scopus
Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles
Ultrasound in Medicine and Biology, vol. 47, no. 6, pp. 1596-1615Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ultrasmedbio.2021.02.001
- [ONLINE] View publication in Scopus
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
Cell Reports, vol. 35, no. 8, 109153Contributions to Journals: ArticlesUltrasound-Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model
International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1472-1482Contributions to Journals: ArticlesSPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells
Cell Death and Disease, vol. 12, no. 2, 165Contributions to Journals: ArticlesGreater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer
Journal of Pathology: Clinical Research, vol. 6, no. 4, pp. 238-251Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cjp2.167
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17424/1/Ottley_etal_JPCR_Greater_utility_of_VOR.pdf
- [ONLINE] View publication in Scopus
Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation
BMC Biology, vol. 18, 102Contributions to Journals: ArticlesThe Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo
International Journal of Radiation Oncology Biology Physics, vol. 107, no. 1, pp. 212-221Contributions to Journals: ArticlesEAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort: Under the Auspices of the EAU-ESMO Guidelines Committees
European Urology, vol. 77, no. 2, pp. 223-250Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2020.03.017
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15380/1/EAU_ESMO_Bladder_Cancer_Consensus_Eur_Urol_MANUSCRIPT_AND_TABLES_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15380/2/EAU_ESMO_Bladder_Cancer_Consensus_Eur_Urol_SI_Appendix_AAM.pdf
The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
EMBO Journal, vol. 38, no. 21, e102361Contributions to Journals: ArticlesMRE11A Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation
Bladder Cancer, vol. 5, no. 2, pp. 147-157Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/BLC-190209
- [ONLINE] View publication in Scopus
MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer
International Journal of Radiation Oncology Biology Physics, vol. 104, no. 4, pp. 809-818Contributions to Journals: ArticlesMouse Models of Muscle-invasive Bladder Cancer: Key Considerations for Clinical Translation Based on Molecular Subtypes
European Urology Oncology, vol. 2, no. 3, pp. 239-247Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.euo.2018.08.014
- [ONLINE] View publication in Scopus
Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer
JAMA Surgery, vol. 154, no. 2, pp. 185-186Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1001/jamasurg.2018.4370
- [ONLINE] View publication in Scopus
Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future
Urologic Oncology: Seminars and Original Investigations, vol. 36, no. 9, pp. 413-422Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.urolonc.2017.10.014
- [ONLINE] View publication in Scopus
Recommendations for follow-up of muscle-invasive bladder cancer patients: A consensus by the international bladder cancer network
Urologic Oncology: Seminars and Original Investigations, vol. 36, no. 9, pp. 423-431Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.urolonc.2018.01.014
- [ONLINE] View publication in Scopus
Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer
British Journal of Cancer, vol. 119, no. 2, pp. 220-229Contributions to Journals: ArticlesContemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer
Clinical genitourinary cancer, vol. 16, no. 3, pp. 213-218Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.clgc.2017.11.004
- [ONLINE] View publication in Scopus
High Levels of Patient Satisfaction in Joint Uro-oncology Clinics to Assist Patient Choice in Early Prostate Cancer and Muscle-invasive Bladder Cancer
Clinical Oncology, vol. 30, no. 4, pp. e39Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.clon.2018.01.004
- [ONLINE] View publication in Scopus
Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity
Molecular Cancer Therapeutics, vol. 17, no. 2, pp. 381-392Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1535-7163.MCT-17-0011
- [ONLINE] View publication in Scopus
Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset
European Urology, vol. 72, no. 3, pp. 354-365Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2017.03.010
- [ONLINE] View publication in Scopus
No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy
British Journal of Cancer, vol. 117, no. 3, pp. 322-325Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2017.188
- [ONLINE] View publication in Scopus
The Impact of Histological Variants of Urothelial Carcinoma on Clinical Outcomes Following Trimodality Bladder-sparing Chemoradiation
European Urology, vol. 72, no. 1, pp. 61-63Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2017.01.045
- [ONLINE] View publication in Scopus
E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer
Cancer Research, vol. 77, no. 11, pp. 3027-3029Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-16-3232
- [ONLINE] View publication in Scopus
The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction?
Clinical Oncology, vol. 29, no. 6, pp. 344-347Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.clon.2017.01.040
- [ONLINE] View publication in Scopus
Crowdsourcing for translational research: Analysis of biomarker expression using cancer microarrays
British Journal of Cancer, vol. 116, no. 2, pp. 237-245Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2016.404
- [ONLINE] View publication in Scopus
Biomarkers of Tumour Radiosensitivity and Predicting Benefit from Radiotherapy
Clinical Oncology, vol. 27, no. 10, pp. 561-569Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.clon.2015.06.002
- [ONLINE] View publication in Scopus
Bladder-sparing strategies for invasive bladder cancer
Advances in Bladder Cancer Management. Future Medicine Ltd., pp. 158-173, 16 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.2217/fmeb2013.13.7
- [ONLINE] View publication in Scopus
Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of european ancestry
Human Molecular Genetics, vol. 25, no. 6, pp. 1203-1214Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddv492
- [ONLINE] View publication in Scopus
Treatment of Breast and Prostate Cancer by Hypofractionated Radiotherapy: Potential Risks and Benefits
Clinical Oncology, vol. 27, no. 7, pp. 420-426Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.clon.2015.02.008
- [ONLINE] View publication in Scopus
High-throughput DNA sequencing identifies novel CtIP (RBBP8) variants in muscle-invasive bladder cancer patients
Bladder Cancer, vol. 1, no. 1, pp. 31-44Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/BLC-150007
- [ONLINE] View publication in Scopus
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer
Human Molecular Genetics, vol. 23, no. 20, pp. 5545-5557Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddu264
- [ONLINE] View publication in Scopus
Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer
Clinical Cancer Research, vol. 20, no. 21, pp. 5435-5445Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-14-0542
- [ONLINE] View publication in Scopus
Re: Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review
European Urology, vol. 66, no. 3, pp. 597-598Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2014.06.033
- [ONLINE] View publication in Scopus
Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology
Journal of Materials Science, vol. 49, no. 17, pp. 5809-5820Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/s10853-014-8325-x
- [ONLINE] View publication in Scopus
Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden
Nature Communications, vol. 5, 3756Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ncomms4756
- [ONLINE] View publication in Scopus
Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer
Annals of Oncology, vol. 25, no. 4, pp. 877-883Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/annonc/mdu014
- [ONLINE] View publication in Scopus
Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours
Oncotarget, vol. 5, no. 4, pp. 993-1003Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.1627
- [ONLINE] View publication in Scopus
Can γH2AX be used to personalise cancer treatment?
Current molecular medicine, vol. 13, no. 10, pp. 1591-1602Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.2174/1566524013666131111124531
- [ONLINE] View publication in Scopus
Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression
Radiotherapy and Oncology, vol. 108, no. 3, pp. 429-433Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.radonc.2013.06.021
- [ONLINE] View publication in Scopus
The emerging role of histone deacetylase (HDAC) inhibitors in urological cancers
BJU International, vol. 111, no. 4, pp. 537-542Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1111/j.1464-410X.2012.11647.x
- [ONLINE] View publication in Scopus
Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair
British Journal of Cancer, vol. 108, no. 4, pp. 748-754Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2013.21
- [ONLINE] View publication in Scopus
Imatinib radiosensitizes bladder cancer by targeting homologous recombination
Cancer Research, vol. 73, no. 5, pp. 1611-1620Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-12-1170
- [ONLINE] View publication in Scopus
The role of microrna-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes
Carcinogenesis, vol. 33, no. 3, pp. 581-586Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/carcin/bgr300
- [ONLINE] View publication in Scopus
Using gene polymorphisms to assess bladder cancer risk: Progress and challenges
Journal of Urology, vol. 187, no. 2, pp. 379-380Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.juro.2011.11.002
- [ONLINE] View publication in Scopus
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene
Human Molecular Genetics, vol. 20, no. 21, pp. 4268-4281Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddr303
- [ONLINE] View publication in Scopus
Radiotherapy for node positive penile cancer: Experience of the leeds teaching hospitals
Journal of Urology, vol. 186, no. 2, pp. 524-529Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.juro.2011.03.117
- [ONLINE] View publication in Scopus
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients
BMC Medical Genetics, vol. 12, 84Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2350-12-84
- [ONLINE] View publication in Scopus
In vitro functional effects of XPC gene rare variants from bladder cancer patients
Carcinogenesis, vol. 32, no. 4, pp. 516-521Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/carcin/bgr005
- [ONLINE] View publication in Scopus
Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer
Journal of Clinical Oncology, vol. 29, no. 6, pp. 733-738Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1200/JCO.2010.31.5721
- [ONLINE] View publication in Scopus
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nature Genetics, vol. 42, no. 11, pp. 978-984Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.687
- [ONLINE] View publication in Scopus
MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer
Cancer Research, vol. 70, no. 18, pp. 7017-7026Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-10-1202
- [ONLINE] View publication in Scopus
Common predisposition alleles for moderately common cancers: Bladder cancer
Current Opinion in Genetics and Development, vol. 20, no. 3, pp. 218-224Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.gde.2010.01.002
- [ONLINE] View publication in Scopus
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 42, no. 5, pp. 415-419Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.558
- [ONLINE] View publication in Scopus
Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer
Cancer Research, vol. 69, no. 17, pp. 6857-6864Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-09-1091
- [ONLINE] View publication in Scopus
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 41, no. 9, pp. 991-995Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.421
- [ONLINE] View publication in Scopus
Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities
Genes Chromosomes and Cancer, vol. 48, no. 4, pp. 310-321Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/gcc.20641
- [ONLINE] View publication in Scopus
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
Nature Genetics, vol. 41, no. 2, pp. 221-227Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.296
- [ONLINE] View publication in Scopus
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
Molecular Cancer Therapeutics, vol. 8, no. 1, pp. 203-213Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1535-7163.MCT-08-0959
- [ONLINE] View publication in Scopus
Cancer biomarkers associated with damage response genes
The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer Netherlands, pp. 307-330, 24 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-90-481-2561-6_14
- [ONLINE] View publication in Scopus
Molecular epidemiology of DNA repair genes in bladder cancer
Cancer Epidemiology: Volume II: Modifiable Factors. Verma, M. (ed.), pp. 281-306, 26 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-60327-492-0_12
- [ONLINE] View publication in Scopus
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 40, no. 11, pp. 1307-1312Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.229
- [ONLINE] View publication in Scopus
In Reply to Dr. Rosario et al.
International Journal of Radiation Oncology Biology Physics, vol. 71, no. 5, pp. 1602Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.ijrobp.2008.03.038
- [ONLINE] View publication in Scopus
Analysis of variants in DNA damage signalling genes in bladder cancer
BMC Medical Genetics, vol. 9, 69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2350-9-69
- [ONLINE] View publication in Scopus
Similar Treatment Outcomes for Radical Cystectomy and Radical Radiotherapy in Invasive Bladder Cancer Treated at a United Kingdom Specialist Treatment Center
International Journal of Radiation Oncology Biology Physics, vol. 70, no. 2, pp. 456-463Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ijrobp.2007.06.030
- [ONLINE] View publication in Scopus
DNA repair gene XRCC1 polymorphisms and bladder cancer risk
BMC Genetics, vol. 8, 13Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2156-8-13
- [ONLINE] View publication in Scopus
Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk
Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 12, pp. 2537-2541Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1055-9965.EPI-06-0288
- [ONLINE] View publication in Scopus
APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer
Clinical Cancer Research, vol. 11, no. 17, pp. 6205-6211Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-05-0045
- [ONLINE] View publication in Scopus
The polyAT, intronic IVSII-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder
British Journal of Cancer, vol. 92, no. 12, pp. 2262-2265Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6602616
- [ONLINE] View publication in Scopus
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts
Nucleic Acids Research, vol. 33, no. 8, pp. 2531-2539Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gki528
- [ONLINE] View publication in Scopus
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
Nucleic Acids Research, vol. 32, no. 17, pp. 5249-5259Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gkh842
- [ONLINE] View publication in Scopus
Double strand break repair by non-homologous end joining in bladder cancer
European Urology, Supplements, vol. 2, no. 6, pp. 90Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S1569-9056(03)90451-9
- [ONLINE] View publication in Scopus
Development of a rapid, small-scale DNA repair assay for use on clinical samples.
Nucleic Acids Research, vol. 31, no. 15, pp. e83Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gng083
- [ONLINE] View publication in Scopus
Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer
Radiotherapy and Oncology, vol. 55, no. 2, pp. 179-186Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0167-8140(99)00158-9
- [ONLINE] View publication in Scopus
Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy
Radiation Research, vol. 153, no. 5 I, pp. 570-578Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1667/0033-7587(2000)153[0570:DOIDIR]2.0.CO;2
- [ONLINE] View publication in Scopus
Iridium-192 implantation for node-negative carcinoma of the penis: The Cookridge Hospital experience
Clinical Oncology, vol. 12, no. 1, pp. 25-31Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1053/clon.2000.9106
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The need for the moving junction in craniospinal irradiation
British Journal of Radiology, vol. 73, no. 870, pp. 650-654Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1259/bjr.73.870.10911789
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A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients
Radiotherapy and Oncology, vol. 51, no. 1, pp. 55-65Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0167-8140(99)00030-4
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Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients
International Journal of Radiation Oncology Biology Physics, vol. 43, no. 3, pp. 481-487Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0360-3016(98)00392-7
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Fibroblast radiosensitivity measured using the comet DNA-damage assay correlates with clonogenic survival parameters
British Journal of Cancer, vol. 79, no. 9-10, pp. 1366-1371Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6690219
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Training to treat cancer: Future developments
Hospital Medicine, vol. 60, no. 7, pp. 519-521Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.12968/hosp.1999.60.7.1160
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DNA damage assays in normal tissue radiosensitivity testing
British Journal of Radiology, vol. 71, no. JAN., pp. 103Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity
British Journal of Cancer, vol. 78, no. 12, pp. 1559-1563Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.1998.723
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A correlation between residual dna double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients
International Journal of Radiation Oncology Biology Physics, vol. 39, no. 5, pp. 1137-1144Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0360-3016(97)00545-2
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Ondansetron versus a chlorpromazine and dexamethasone combination for the prevention of nausea and vomiting: A prospective, randomised study to assess efficacy, cost effectiveness and quality of life following single- fraction radiotherapy
Supportive Care in Cancer, vol. 5, no. 6, pp. 500-503Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s005200050119
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SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells
Nucleic Acids Research, vol. 25, no. 14, pp. 2945-2946Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/25.14.2945
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Relapse of intracranial germinoma 23 years postirradiation in a patient given growth hormone replacement
Medical and Pediatric Oncology, vol. 29, no. 1, pp. 41-44Contributions to Journals: ArticlesSurvival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old
Medical and Pediatric Oncology, vol. 28, no. 5, pp. 348-354Contributions to Journals: ArticlesSurvival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972–1993
Medical and Pediatric Oncology, vol. 25, no. 6, pp. 450-456Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mpo.2950250606
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Army Cardiac Unit -- cardiac catheter patients, 1991--a review.
Journal of the Royal Army Medical Corps, vol. 140, no. 2, pp. 79-85Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jramc-140-02-06
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