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Dr Anke Roelofs

Dr Anke Roelofs
Dr Anke Roelofs
Dr Anke Roelofs

MSc, DPhil, FHEA

Senior Lecturer

About
Email Address
a.roelofs@abdn.ac.uk
Office Address

Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
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Biography

I completed my MSc in Biology, with specialisation in Medical Biology, at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford, where I obtained my DPhil in Medical Science in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).

Qualifications

  • MSc Biology 
    2003 - University of Groningen 
  • DPhil Medical Sciences 
    2007 - University of Oxford 
  • FHEA Fellow of the Higher Education Academy 
    2023 - Advance HE 
Research

Current Research

My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.

Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.

Teaching

Programmes

Courses

Publications

Page 4 of 5 Results 31 to 40 of 46

  • Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

    Roelofs, A. J., Thompson, K., Ebetino, F., Rogers, M. J., Coxon, F.
    Current Pharmaceutical Design, vol. 16, no. 27, pp. 2950-2960
    Contributions to Journals: Review articles

  • A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells

    Ford, L. A., Roelofs, A. J., Anavi-Goffer, S., Mowat, L., Simpson, D. G., Irving, A. J., Rogers, M. J., Rajnicek, A. M., Ross, R. A.
    British Journal of Pharmacology, vol. 160, no. 3, pp. 762-771
    Contributions to Journals: Articles

  • Bisphosphonates: mechanisms of action

    Roelofs, A. J., Rogers, M.
    Handbook of Cancer-Related Bone Disease. Coleman, R. E., Abrahamsson, P. A., Hadji, P. (eds.). BioScientifica, pp. 71-89, 19 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

    Roelofs, A. J., Coxon, F., Ebetino, F. H., Lundy, M. W., Henneman, Z. J., Nancollas, G. H., Sun, S., Blazewska, K. M., Lynn F Bala, J., Kashemirov, B. A., Khalid, A. B., McKenna, C. E., Rogers, M. J.
    Journal of Bone and Mineral Research, vol. 25, no. 3, pp. 606-616
    Contributions to Journals: Articles

  • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation

    Guenther, A., Gordon, S., Tiemann, M., Burger, R., Bakker, F., Green, J. R., Baum, W., Roelofs, A. J., Rogers, M. J., Gramatzki, M.
    International Journal of Cancer, vol. 126, no. 1, pp. 239-246
    Contributions to Journals: Articles

  • Activation of γδ T Cells by Bisphosphonates

    Thompson, K., Roelofs, A. J., Jauhiainen, M., Mönkkönen, H., Mönkkönen, J., Rogers, M. J.
    Advances in Experimental Medicine and Biology, vol. 658, pp. 11-20
    Contributions to Journals: Review articles

  • The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

    Hirbe, A. C., Roelofs, A. J., Floyd, D. H., Deng, H., Becker, S. N., Lanigan, L. G., Apicelli, A. J., Xu, Z., Prior, J. L., Eagleton, M. C., Piwnica-Worms, D., Rogers, M. J., Weilbaecher, K.
    Bone, vol. 44, no. 5, pp. 908-916
    Contributions to Journals: Articles

  • Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP

    Roelofs, A. J., Jauhiainen, M., Monkkonen, H., Rogers, M. J., Monkkonen, J., Thompson, K.
    British Journal of Haematology, vol. 144, no. 2, pp. 245-250
    Contributions to Journals: Articles

  • Fluorescently labeled risedronate and related analogues: “Magic Linker” Synthesis

    Kashemirov, B. A., Bala, J. L. F., Chen, X., Ebetino, F. H., Xia, Z., Russell, R. G. G., Coxon, F., Roelofs, A. J., Rogers, M. J., McKenna, C. E.
    Bioconjugate Chemistry, vol. 19, no. 12, pp. 2308-2310
    Contributions to Journals: Articles

  • Bisphosphonates: Mechanisms of action

    Roelofs, A. J., Frank H Ebetino, F. H., Reszka, A. A., Russell, R. G. G., Rogers, M.
    Principles of Bone Biology: Volume 2. Bilezikian, J. P., Raisz, L. G., Martin, T. J. (eds.). 3 edition. Academic Press, pp. 1737-1767
    Chapters in Books, Reports and Conference Proceedings: Chapters
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