Dr Anke Roelofs
MSc, DPhil, FHEA
Senior Lecturer
- About
-
- Email Address
- a.roelofs@abdn.ac.uk
- Office Address
Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I completed my MSc in Biology, with specialisation in Medical Biology, at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford, where I obtained my DPhil in Medical Science in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).
Qualifications
- MSc Biology2003 - University of Groningen
- DPhil Medical Sciences2007 - University of Oxford
- FHEA Fellow of the Higher Education Academy2023 - Advance HE
- Research
-
Current Research
My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.
Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.
- Teaching
-
Programmes
- Postgraduate, 3 stage, September start
Programme coordinator
Courses
Course coordinator
- Student Selected Component 1 (ME2511)
- Publications
-
Page 1 of 1 Results 1 to 46 of 46
Recognition and control of neutrophil extracellular trap formation by MICL
Nature, vol. 633, no. 8029, pp. 442-450Contributions to Journals: ArticlesDisentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Osteoarthritis and CartilageContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2024.07.006
Vascular disease persistence in giant cell arteritis: are stromal cells neglected?
Annals of the Rheumatic DiseasesContributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1136/ard-2023-225270
Osteoarthritis year in review 2023: Biology
Osteoarthritis and Cartilage, vol. 32, no. 2, pp. 148-158Contributions to Journals: ArticlesBMP signalling: A significant player and therapeutic target for osteoarthritis
Osteoarthritis and Cartilage, vol. 31, no. 11, pp. 1454-1468Contributions to Journals: ArticlesSpatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Journal of Bone and Mineral Research, vol. 38, no. 5, pp. 792-807Contributions to Journals: ArticlesTaxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Annals of the Rheumatic Diseases, vol. 82, no. 3, pp. 428-437Contributions to Journals: ArticlesCellular therapy and tissue engineering for cartilage repair
Osteoarthritis and Cartilage, vol. 30, no. 12, pp. 1547-1560Contributions to Journals: Review articlesTargeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
Annals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224Contributions to Journals: ArticlesHuman Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model
Cells, vol. 10, no. 8, 1999Contributions to Journals: ArticlesIdentification of the skeletal progenitor cells forming osteophytes in osteoarthritis
Annals of the Rheumatic Diseases, vol. 79, no. 12, pp. 1625-1634Contributions to Journals: ArticlesAgrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Science translational medicine, vol. 12, no. 559, eaax9086Contributions to Journals: ArticlesStem and progenitor cells in synovium
Encyclopedia of Bone Biology. Zaidi, M. (ed.). Elsevier, pp. 96-108, 13 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-801238-3.11160-2
- [ONLINE] View publication in Scopus
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
Scientific Reports, vol. 10, 157Contributions to Journals: ArticlesThe burden of metabolic syndrome on osteoarthritic joints
Arthritis Research & Therapy, vol. 21, 289Contributions to Journals: Review articlesImmunostaining of Skeletal Tissues
Methods in molecular biology (Clifton, N.J.), vol. 1914, pp. 437-450Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-8997-3_25
Stem Cell-based Therapeutic Strategies for Cartilage Defects and Osteoarthritis
Current Opinion in Pharmacology, vol. 40, pp. 74-80Contributions to Journals: Review articlesAdipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
Molecular Metabolism, vol. 10, pp. 55-65Contributions to Journals: ArticlesJoint morphogenetic cells in the adult mammalian synovium
Nature Communications, vol. 8, 15040Contributions to Journals: ArticlesMesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?
Current Opinion in Rheumatology, vol. 29, no. 2, pp. 201-207Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1097/BOR.0000000000000370
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10119/1/Ansboro_et_al_revised.pdf
- [ONLINE] View publication in Scopus
Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury
Arthritis Research & Therapy, vol. 18, 166Contributions to Journals: ArticlesFluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Bioconjugate Chemistry, vol. 27, no. 2, pp. 329-340Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acs.bioconjchem.5b00369
Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
Arthritis Research & Therapy, vol. 17, 147Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0639-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7388/1/s13075_015_0639_9.pdf
In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum
European Cells & Materials, vol. 27, pp. 185-195Contributions to Journals: ArticlesCell-based Approaches to Joint Surface Repair: A Research Perspective
Osteoarthritis and Cartilage, vol. 21, no. 7, pp. 892-900Contributions to Journals: Review articlesBisphosphonates: Mechanisms of action
Handbook of cancer-related bone disease. Coleman, R., Abrahamsson, P., Hadji, P. (eds.). 2 edition. BioScientifica, pp. 75-99, 25 pagesChapters in Books, Reports and Conference Proceedings: ChaptersInfluence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
Journal of Bone and Mineral Research, vol. 27, no. 4, pp. 835-847Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.1543
Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth
Cancer, vol. 118, no. 3, pp. 750-760Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cncr.26336
Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field
European Cells & Materials, vol. 22, no. -, pp. 344-358Contributions to Journals: ArticlesSynthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs
Phosphorus, Sulfur and SIlicon and the Related Elements, vol. 186, no. 4, pp. 970-971Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/10426507.2010.526674
- [ONLINE] View publication in Scopus
Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages
Current Pharmaceutical Design, vol. 16, no. 27, pp. 2950-2960Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.2174/138161210793563635
A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells
British Journal of Pharmacology, vol. 160, no. 3, pp. 762-771Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1476-5381.2010.00743.x
Bisphosphonates: mechanisms of action
Handbook of Cancer-Related Bone Disease. Coleman, R. E., Abrahamsson, P. A., Hadji, P. (eds.). BioScientifica, pp. 71-89, 19 pagesChapters in Books, Reports and Conference Proceedings: ChaptersFluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
Journal of Bone and Mineral Research, vol. 25, no. 3, pp. 606-616Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1359/jbmr.091009
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation
International Journal of Cancer, vol. 126, no. 1, pp. 239-246Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.24758
Activation of γδ T Cells by Bisphosphonates
Advances in Experimental Medicine and Biology, vol. 658, pp. 11-20Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-4419-1050-9_2
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
Bone, vol. 44, no. 5, pp. 908-916Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bone.2009.01.010
Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP
British Journal of Haematology, vol. 144, no. 2, pp. 245-250Contributions to Journals: ArticlesFluorescently labeled risedronate and related analogues: “Magic Linker” Synthesis
Bioconjugate Chemistry, vol. 19, no. 12, pp. 2308-2310Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/bc800369c
Bisphosphonates: Mechanisms of action
Principles of Bone Biology: Volume 2. Bilezikian, J. P., Raisz, L. G., Martin, T. J. (eds.). 3 edition. Academic Press, pp. 1737-1767Chapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-373884-4.00095-1
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
Bone, vol. 42, no. 5, pp. 848-860Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/J.BONE.2007.12.225
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 1, pp. 228-235Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1124/jpet.106.116467
Differential Effects of Stress on Adult Hippocampal Cell Proliferation in Low and High Aggressive Mice
Journal of Neuroendocrinology, vol. 19, no. 7, pp. 489-498Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2826.2007.01555.x
Apomine (TM), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo
International Journal of Cancer, vol. 120, no. 8, pp. 1657-1663Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.22478
Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells
International Journal of Cancer, vol. 119, no. 6, pp. 1254-1261Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.21977
Molecular mechanisms of action of bisphosphonates: current status
Clinical Cancer Research, vol. 12, no. 20 PT 2, pp. 6222S-6230SContributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-06-0843
