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The School of Natural and Computing Sciences

Professor M Carmen Romano

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Professor M Carmen Romano
Professor M Carmen Romano
Professor M Carmen Romano

Personal Chair

About
Email Address
m.romano@abdn.ac.uk
Telephone Number
+44 (0)1224 272507
Office Address
Office 337, Institute for Complex Systems and Mathematical Biology, Department of Physics, Meston Building, Old Aberdeen Office 3:47, Institute of Medical Sciences, Foresterhill
School/Department
School of Natural and Computing Sciences
Research

Research Overview

I am interested in the understanding of fundamental biological processes using theoretical approaches based on nonlinear dynamics and statistical physics and combining them with experimental data. In particular, I am interested in the process of translation or synthesis of proteins, the coupling between transcription and translation, how ribosomes, the molecular machines that manufacture proteins, are synthesised, and its relationship to the cell cycle. I am furthermore interested in the effect of combinatorial stresses in yeast, as well as the effects of different types of stress on the cell cycle.

Funding and Grants

SULSA studentship (modeling of translation)/ SABR grant (Combinatorial Responses In Stress Pathways)/BBSRC grant (Ribosome Traffic Flow on the mRNA as a Regulator of Cellular Protein Production)
Teaching

Teaching Responsibilities

Electromagnetism (PX3008, 3rd year Physics) and Introduction to Mathematics and Modelling of Biological Systems (SB5005, MSc in Cell and Molecular Systems Biology)

Publications

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  • Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation

    Gorgoni, B., Ciandrini, L., McFarland, M. R., Romano, M. C., Stansfield, I.
    Nucleic Acids Research, vol. 44, no. 19, pp. 9231-9244
    Contributions to Journals: Articles

  • Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans

    Chandrasekaran, K., Kaloriti, D., Tillmann, A. T., Yin, Z., Herrero De Dios, C., Jacobsen, M. D., Belmonte, R. C., Cameron, G., Haynes, K., Grebogi, C., de Moura, A. P. S., Gow, N. A. R., Thiel, M., Quinn, J., Brown, A. J. P., Romano, M. C.
    PloS ONE, vol. 10, no. 9, 0137750
    Contributions to Journals: Articles

  • Minimal model of transcriptional elongation processes with pauses

    Wang, J., Pfeuty, B., Thommen, Q., Romano Blasco, M. C., Lefranc, M.
    Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 90, no. 5, pp. 1-4
    Contributions to Journals: Articles

  • Ribosome recycling induces optimal translation rate at low ribosomal availability

    Marshall, E., Stansfield, I., Romano, M. C.
    Journal of the Royal Society Interface, vol. 11, no. 98, 20140589
    Contributions to Journals: Articles

  • Stepping and Crowding of Molecular Motors: Statistical Kinetics from an Exclusion Process Perspective

    Ciandrini, L., Romano, M. C., Parmeggiani, A.
    Biophysical Journal, vol. 107, no. 5, pp. 1176-1184
    Contributions to Journals: Articles

  • Identifying coupling directions by recurrences

    Zou, Y., Romano, M. C., Thiel, M., Kurths, J.
    Recurrence Quantification Analysis: Theory and Best Practices - Part I. Webber Jr, C. L., Marwan, N. (eds.). Springer Verlag, pp. 65-99, 35 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA

    Gorgoni, B., Marshall, E., McFarland, M. R., Romano, M. C., Stansfield, I.
    Biochemical Society Transactions, vol. 42, no. 1, pp. 160-165
    Contributions to Journals: Articles

  • Dominant-negative release factors and their effect on termination and translational recoding events

    McFarland, M. R., Romano, M. C., Stansfield, I.
    RNA UK 2014
    Contributions to Conferences: Posters

  • The wiper model: avalanche dynamics in an exclusion process

    Politi, A., Romano, M. C.
    Journal of statistical mechanics-Theory and experiment, vol. 2013, 10015
    Contributions to Journals: Articles

  • From START to FINISH: the influence of osmotic stress on the cell cycle

    Radmaneshfar, E., Kaloriti, D., Gustin, M. C., Gow, N. A. R., Brown, A. J. P., Grebogi, C., Romano, M. C., Thiel, M.
    PloS ONE, vol. 8, no. 7, e68067
    Contributions to Journals: Articles
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