Personal Chair
- About
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- Email Address
- m.romano@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272507
- Office Address
- Office 337, Institute for Complex Systems and Mathematical Biology, Department of Physics, Meston Building, Old Aberdeen Office 3:47, Institute of Medical Sciences, Foresterhill
- School/Department
- School of Natural and Computing Sciences
- Research
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Research Overview
I am interested in the understanding of fundamental biological processes using theoretical approaches based on nonlinear dynamics and statistical physics and combining them with experimental data. In particular, I am interested in the process of translation or synthesis of proteins, the coupling between transcription and translation, how ribosomes, the molecular machines that manufacture proteins, are synthesised, and its relationship to the cell cycle. I am furthermore interested in the effect of combinatorial stresses in yeast, as well as the effects of different types of stress on the cell cycle.
Funding and Grants
SULSA studentship (modeling of translation)/ SABR grant (Combinatorial Responses In Stress Pathways)/BBSRC grant (Ribosome Traffic Flow on the mRNA as a Regulator of Cellular Protein Production)
- Teaching
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Teaching Responsibilities
Electromagnetism (PX3008, 3rd year Physics) and Introduction to Mathematics and Modelling of Biological Systems (SB5005, MSc in Cell and Molecular Systems Biology)
- Publications
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Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
Nucleic Acids Research, vol. 44, no. 19, pp. 9231-9244Contributions to Journals: ArticlesIntegrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
PloS ONE, vol. 10, no. 9, 0137750Contributions to Journals: ArticlesMinimal model of transcriptional elongation processes with pauses
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 90, no. 5, pp. 1-4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.90.050701
Ribosome recycling induces optimal translation rate at low ribosomal availability
Journal of the Royal Society Interface, vol. 11, no. 98, 20140589Contributions to Journals: ArticlesStepping and Crowding of Molecular Motors: Statistical Kinetics from an Exclusion Process Perspective
Biophysical Journal, vol. 107, no. 5, pp. 1176-1184Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bpj.2014.07.012
Identifying coupling directions by recurrences
Recurrence Quantification Analysis: Theory and Best Practices - Part I. Webber Jr, C. L., Marwan, N. (eds.). Springer Verlag, pp. 65-99, 35 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-07155-8_3
- [ONLINE] View publication in Scopus
Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA
Biochemical Society Transactions, vol. 42, no. 1, pp. 160-165Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/BST20130132
Dominant-negative release factors and their effect on termination and translational recoding events
RNA UK 2014Contributions to Conferences: PostersThe wiper model: avalanche dynamics in an exclusion process
Journal of statistical mechanics-Theory and experiment, vol. 2013, 10015Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1088/1742-5468/2013/10/P10015
From START to FINISH: the influence of osmotic stress on the cell cycle
PloS ONE, vol. 8, no. 7, e68067Contributions to Journals: Articles