Monoamine oxidase-B (MAO-B) breaks down dopamine secreted by neurones and is predominantly found in dopamine containing regions on the central nervous system. By inhibiting it, there is an increase in dopamine in the basal ganglia.
MAO-B inhibitors are specific and patients do not get the same side effects as they do with antidepressant non-selective MAO inhibitors.
Oral.
Particular problems are noted with:
- Pethidine - can cause hyperpyrexia and CNS toxicity.
- Adrenaline- Increased risk of hypertensive crisis.
- Anti-depressants - risk of serotonin syndrome
- MAOI antidepressants - increased risk of hypotension
- Combined hormonal contraceptives- increases the exposure to MAO-B inhibitors
- Tyramine rich food and drinks (e.g. cheese, salami and wine)-can cause hypertension with high dose MAO-B Inhibitor treatment.
Avoid abrupt withdrawal and should be aware of potential side effects.
Nil relevant.
