Gold
Examples
Indications
Contraindications
Contraindications
- Haematological disorders
- Exfoliative dermatitis
- SLE
- Severe renal impairment
- Severe hepatic impairment
- Pregnancy and breast-feeding
Cautions
- Elderly
- History of eczema / urticaria
Mechanism
The mechanism by which gold salts suppress inflammation is not well understood.
Administration
Intramuscular
Adverse Reactions
- Anaphylactoid reactions
- Rash and pigmentation on sun exposed areas
- Bone marrow suppression
- Proteinuria (including nephrotic syndrome)
- GI upset
- Hepatotoxicity (cholestatic jaundice)
- Pulmonary fibrosis
Interactions
Risk of severe skin reaction when used with chloroquine.
Risk of toxicity if given with penicillamine.
Hypotension occurs if used with ACE inhibitors.
Education
Patients should be aware that monitoring tests are needed. They should also be aware of important side effects to look out for.
Pharmacokinetics
Widely distributed and may accumulate, meaning that it can be detected for up to one year after use. Renal excretion.
