Prostaglandins for Obstetric Use
- Gemeprost
- Dinoprostone
- (Misoprostol)
- Induction and augmentation of labour
- Post-partum haemorrhage (second line treatment)
- Induction of abortion
Different prostaglandins are used for different indications and are not interchangeable.
Other uses include glaucoma, erectile dysfunction and pulmonary hypertension.
Prostaglandins are naturally occurring compounds. One of their actions is to contract the uterus (pregnant and non-pregnant) and cause cervical dilatation by activating collagenase in the cervix. The sensitivity of uterine muscles increases during pregnancy. Contraction results in expulsion of uterine contents.
Their role in parturition is incompletely understood.
Prostaglandins have a range of actions in the body which include: reduction in gastric acid and increase in gastric mucus, bronchodilation / constriction, increased renal blood flow, vasodilatation, inhibition of platelet aggregation and reduction of intraocular pressure.
Used under specialist guidance - nil of note.
Prostaglandins enter the systemic circulation, but are rapidly metabolised so that most effects are local, particularly if given topically. Excreted by the kidneys.
