Echinocanadins

Examples
Indications
Echinocanadins are only active against species of Aspergillus and Candida.
Contraindications
Contraindications Cautions
Mechanism
Echinocanadins are inhibitors of glucan synthase, an enzyme needed to produce beta (1,3)-D-glucan, an essential component for fungal cell wall stability.
Administration
Echinocandins can only be administered intravenously at present.
Adverse Reactions
Common side effects include; Less common but significant side effects include;
Interactions
Dexamethasone, phenytoin and rifampicin all reduce caspofungin levels.
Education
Nil
Pharmacokinetics
Echinocanadins bind extensively to albumin and can take up to 2 days to distribute fully into tissue.