Somatostatin Analogues

Examples
Indications
Note; octreotide is a symptomatic treatment.

It is also used in reducing variceal bleeding and in reducing vomiting in palliative care, as unlicensed indications.
Contraindications
Caution
Mechanism
Octreotide and Lanreotide are long-acting somatostatin analogues. Somatostatin inhibits production of growth hormone and IGF-1, along with a range of other effects on the GI tract. It is therefore, treatment of choice in acromegaly and a range of endocrine tumours, assuming debulking pituitary surgery is not required.
Administration
Given parenterally, usually subcutaneously or occasionally intravenously.

Lanreotide is much longer acting and is therefore preferred, as it can be given weekly or less frequently.
Adverse Reactions
Interactions
Nil of note.
Education
Patients and carers are given extensive input by endocrine nurses.
Pharmacokinetics
Nil of note.