Simvastatin and Amlodipine
Image courtesy of Jérémy Barande
Simvastatin (HMG-CoA reductase inhibitor).
Amlodipine (Calcium channel blocker).
Simvastatin is metabolised by the cytochrome P-450 isoenzyme CYP3A4.
Amlodipine is a weak inhibitor of CYP3A4.
Therefore there is an increased risk of myositis and rhabdomyolysis.
The lipid lowering effect of Simvastatin is increased due to a reduction in its metabolism.
