Page 11

Unwanted effects:

These mainly stem from the blockade of L-type Ca2+ channels in smooth and cardiac muscle.

Low doses may cause:

  • Constipation
  • Flushing
  • Headache
  • Gravitational oedema
    (ankle swelling)

Higher doses may cause:

  • Hypotension
  • Heart failure
  • Bradycardia
  • Heart block