A. Inorrect.
B. Incorrect.
C. Correct. AUC = Dose/Cl. As ciclosporin has the lowest total clearance, it would have the highest AUC value.
Which drug would have the highest AUC after a bolus intravenous dose of 100 mg?
Select one option from the answers below
| Characeristic | amoxicillin | propranolol | ciclosporin |
|---|---|---|---|
| Usual dose (mg) | 250 | 80 | 350 |
| Vd (L) | 29 | 360 | 245 |
| Fraction unbound (fu) | 0.82 | 0.1 | 0.06 |
| Half-life (h) | 0.9 | 4 | 8 |
| Fraction excreted unchanged (fe) | 0.56 | 0.02 | <0.01 |