Case study 2 - Scenario

The table shows the disposition characteristics in a 70-kg man of three drugs.

Now continue to answer the questions associated with this case study.

Characeristicamoxicillinpropranololciclosporin
Usual dose (mg)25080350
Vd (L)29360245
Fraction unbound (fu)0.820.10.06
Half-life (h)0.948
Fraction excreted unchanged (fe)0.560.02<0.01