A. False. Bioavailability is calculated by dividing the AUC of the concentration-time curve after oral administration by the AUC after intravenous administration.
B. False. Any drug molecules that have been distributed in the body are bioavailable whatever the volume in which they have been distributed.
C. True. After intravenous administration all of the dose enters the plasma and is therefore bioavailable.
D. False. Insulin, like other polypeptides and proteins, is denatured by gastric acid and is not bioavailable via the oral route. Insulin is commonly self-administered by patients subcutaneously.
E. False. Many drugs in common use in tablet form have less than 50% oral bioavailability. Drugs with reduced oral bioavailability can be given in higher dose to achieve the necessary plasma concentration.
Which of the following statements concerning bioavailability are true?
Select true or false for each of the following statements