A. False. Plasma clearance is the volume of plasma cleared of drug in a given time often measured in L/hr and is a near constant value. The rate of elimination is measured in mg/hr and is not constant because it depends on the plasma concentration as well as the clearance. The rate of elimination is initially high but declines to zero as the drug is completely eliminated.
B. True.Assuming that the distribution remains in equilibrium it is also the time taken for the plasma concentration to halve. Half-life is a constant in first-order kinetics that describes the time taken for the concentration to halve from any given time point.
C. True. The greater the elimination rate constant, the shorter the half-life (t½ = 0.693/k).
D. False. Half-life is as dependent upon the drug's volume of distribution as it is upon clearance (t½ = 0.693.Vd/Cl).
E. False. There is no consistent difference in half-life between weak bases and weak acids. Weak bases tend to have larger apparent volumes of distribution than weak acids.
Which of the following statements concerning the main concentration-time relationships are true?
Select true or false for each of the following statements