TH1.H2.2D2 Trachea and Extrapulmonary Bronchi

Trachea Epithelium:

  • The epithelium is characterised as a pseudostratified ciliated columnar epithelium with goblet cells
  • It is also known, informally, as respiratory epithelium
  • Examine the luminal surface of the epithelium and notice the extensive cilia which project into the lumen
  • These beat to remove mucus from the respiratory tract and carry it towards the pharynx from where it can be swallowed, or spat out
  • Between the ciliated cells are mucous secreting goblet cells
  • These contribute to the mucus covering the cilia
  • Mucus helps to trap particulate material as well as humidifying the air
  • In the epithelial layer you can see numerous nuclei lying towards the basal surface of the epithelium
  • Most of these are the nuclei of stem cells which can proliferate and then differentiate to form either mucus cells or ciliated cells

Question:

    As we have learned, the mucus from goblet cells and from glands in the connective tissue deep to the epithelium humidifies inspired air, why is this important?

Micrograph of Trachea Epithelium:

    Trachea epithelium

    This micrograph shows the epithelium lining the majority of the upper respiratory tract including the trachea and extrapulmonary bronchi