Lymphoid tissue may be found in defined organs such as the spleen and lymph nodes
However, less defined accumulations of lymphoid tissue can be found: these are collectively known as non-encapsulated lymphoid tissue
These types of lymphoid accumulation range from a cluster of small lymphocytes to fully organised lymphatic nodules in the loose connective tissue of the mucous membrane
In some locations there may be several lymphatic nodules clustered together
These areas include, Peyer's patches in the ileum of the intestine, the appendix and the tonsils in the pharynx
In tonsils, the lymphoid tissue lies in the lamina propria just deep to the surface epithelium
The lymphoid tissue may be so extensive that it extends into the submucosa
As in lymph nodes and spleen, the tonsils contain numerous lymphatic nodules
The epithelium which overlies the tonsil is characteristic of the region in which the tonsil is located
The nasopharyngeal tonsil is located in the nasopharynx which is lined with pseudostratified ciliated columnar epithelium with goblet cells (respiratory epithelium): the lymphoid tissue there is overlain with respiratory epithelium
Where the tonsillar tissue is extensive, the epithelium may give rise to deep infoldings which increase the surface area across which antigens can access the lymphoid tissue and be monitored