The urethra, in both males and females, is lined for the most part with stratified or pseudostratified columnar epithelium
The proximal part of the urethra in both sexes is transitional epithelium and the distal part is stratified squamous epithelium
Overall, the epithelial lining represents a progressive change from the waterproof (urine-proof) transitional (stratified) epithelium of the urinary system to the tough stratified squamous keratinising epithelium of the skin
It is not designed to resist wear and tear and can become damaged during catheterisation if care is not taken
After removal of a catheter, a damaged urethral lining may become fibrosed and cause constrictions leading to difficulties with urination
The female urethra has an indistinct muscular wall
The male urethra is surrounded by, and supported by, the erectile tissue of the penis