What features in the history & examination help to discriminate primary and secondary thrombocytosis?
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Patient well
Generalised pruritus
Skin redness and burning pain
Arterial thrombosis
Splenomegaly
Patient unwell
Fever
Weight loss
Recent surgery
Recent infection
Correct
Incorrect
MPD are often discovered incidentally and patients are usually well. Specific symptoms that may be found in MPD are itch, especially after a warm bath or shower ("aquagenic pruritus") and skin redness and burning pain "erythromelalgia". "B symptoms" such as night sweats and weight loss can occur but are not often present in MPD and they suggest other malignant causes should be sought carefully.
