Dr Thomas Hiscock

Dr Thomas Hiscock

Senior Lecturer

Accepting PhDs

About

Email Address: thomas.hiscock@abdn.ac.uk
Telephone Number: +44 (0)1224 437331
Office Address: UNIVERSITY OF ABERDEEN
Institute of Medical Sciences
School of Medicine, Medical Sciences & Nutrition
Foresterhill Health Campus
ABERDEEN, AB25 2ZD, Scotland, UK
School/Department: School of Medicine, Medical Sciences and Nutrition

ORCiD

Google Scholar

Personal Website

Biography

I originally trained as a theoretical physicist at the University of Cambridge (B.A.,M.Sci), before setting off across the Atlantic to do my Ph.D. at Harvard Medical School. In Sean Megason's lab, I fell in love with embryos, and spent the best part of six years watching them develop under a microscope. In my postdoc, supervised by John Marioni and Ben Simons at the University of Cambridge, I worked on several projects combining my training in physics with my love for developmental biology. In Summer 2020, I started as a Lecturer in Systems Biology at the IMS.

Research

Research Overview

I use mathematical models, computational data analysis and close collaborations with experimentalists to understand development - the remarkable processes that allow single-cell embryos to develop into complex, functional and diverse adult forms. Please see my personal website for more details: https://twhiscock.github.io/

Research Areas

Accepting PhDs

I am currently accepting PhDs in Maths, Biomedical Sciences, Physics.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Maths

Accepting PhDs

View Research Area

Biomedical Sciences

Accepting PhDs

View Research Area

Physics

Accepting PhDs

View Research Area

Research Specialisms

Mathematical Modelling
Developmental Biology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Teaching

Courses

Publications

Page 1 of 1 Results 1 to 17 of 17

Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals
2024 - Published
Grall, E., Feregrino, C., Fischer, S., De Courten, A., Sacher, F., Hiscock, T., Tschopp, P.
Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 2, 2304470121
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.2304470121
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22537/1/Grall_etal_PNAS_Self-Organised_BMP_Signalling_VOR.pdf
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs
2021 - Published
Aztekin, C., Hiscock, T. W., Gurdon, J., Jullien, J., Marioni, J. C., Simons, B. D.
Development, vol. 148, no. 11, dev199158.
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.199158
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16667/1/Aztekin_etal_DEV_Secreted_Inhibitors_Drive_VoR.pdf
A dot-stripe Turing model of joint patterning in the tetrapod limb
2020 - Published
Scoones, J. C., Hiscock, T. W.
Development, vol. 147, no. 8, dev183699
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.183699
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14149/1/Scoones_etal_DB_A_Dot_Stripe_VOR.pdf
- [ONLINE] View publication in Scopus
The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation
2020 - Published
Aztekin, C., Hiscock, T. W., Butler, R., De Jesús Andino, F., Robert, J., Gurdon, J. B., Jullien, J.
Development, vol. 147, no. 3, 185496
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.185496
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14147/1/Aztekin_DB_The_myeloid_lineage_VOR.pdf
- [ONLINE] View publication in Scopus
Navigating at night: fundamental limits on the sensitivity of radical pair magnetoreception under dim light
2019 - Published
Hiscock, H. G., Hiscock, T. W., Kattnig, D. R., Scrivener, T., Lewis, A. M., Manolopoulos, D. E., Hore, P. J.
Quarterly reviews of biophysics, vol. 52, e9
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1017/S0033583519000076
- [ONLINE] View publication in Scopus
- [ONLINE] Oxford University Research Archive
Identification of a regeneration-organizing cell in the Xenopus tail
2019 - Published
Aztekin, C., Hiscock, T. W., Marioni, J. C., Gurdon, J. B., Simons, B. D., Jullien, J.
Science, vol. 364, no. 6441, pp. 653-658
Contributions to Journals: Articles
- [ONLINE] http://science.sciencemag.org/content/364/6441/653/suppl/DC1
- [ONLINE] DOI: https://doi.org/10.1126/science.aav9996
- [ONLINE] View publication in Scopus
Adapting machine-learning algorithms to design gene circuits
2019 - Published
Hiscock, T. W.
BMC Bioinformatics, vol. 20, 214
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s12859-019-2788-3
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14912/1/Hiscock_etal_BMC_Binfo_Adapating_machine_learning_VOR.pdf
- [ONLINE] View publication in Scopus
A single-cell molecular map of mouse gastrulation and early organogenesis
2019 - Published
Pijuan-Sala, B., Griffiths, J. A., Guibentif, C., Hiscock, T. W., Jawaid, W., Calero-Nieto, F. J., Mulas, C., Ibarra-Soria, X., Tyser, R. C., Ho, D. L. L., Reik, W., Srinivas, S., Simons, B. D., Nichols, J., Marioni, J. C., Göttgens, B.
Nature, vol. 566, pp. 490-495
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41586-019-0933-9
- [ONLINE] View publication in Scopus
- [ONLINE] Springer Sharedit link to published PDF
Identity and novelty in the avian syrinx
2018 - Published
Kingsley, E. P., Eliason, C. M., Riede, T., Li, Z., Hiscock, T. W., Farnsworth, M., Thomson, S. L., Goller, F., Tabin, C. J., Clarke, J. A.
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 41, pp. 10209-10217
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.1804586115
- [ONLINE] View publication in Scopus
Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation
2018 - Published
Ishimatsu, K., Hiscock, T. W., Collins, Z. M., Sari, D. W. K., Lischer, K., Richmond, D. L., Bessho, Y., Matsui, T., Megason, S. G.
Development (Cambridge, England), vol. 145, no. 11, dev161257
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.161257
- [ONLINE] View publication in Scopus
Feedback between tissue packing and neurogenesis in the zebrafish neural tube
2018 - Published
Hiscock, T. W., Miesfeld, J. B., Mosaliganti, K. R., Link, B. A., Megason, S. G.
Development (Cambridge), vol. 145, no. 9, 157040
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.157040
- [ONLINE] View publication in Scopus
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
2018 - Published
Liu, T. L., Upadhyayula, S., Milkie, D. E., Singh, V., Wang, K., Swinburne, I. A., Mosaliganti, K. R., Collins, Z. M., Hiscock, T. W., Shea, J., Kohrman, A. Q., Medwig, T. N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E. M., Hockemeyer, D., Drubin, D. G., Martin, B. L., Matus, D. Q., Koyama, M., Megason, S. G., Kirchhausen, T., Betzig, E.
Science, vol. 360, no. 6386, eaaq1392
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1126/science.aaq1392
- [ONLINE] View publication in Scopus
On the Formation of Digits and Joints during Limb Development
2017 - Published
Hiscock, T. W., Tschopp, P., Tabin, C. J.
Developmental Cell, vol. 41, no. 5, pp. 459-465
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1016/j.devcel.2017.04.021
- [ONLINE] View publication in Scopus
Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies
2015 - Published
Hiscock, T. W., Megason, S. G.
Cell Systems, vol. 1, no. 6, pp. 408-416
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cels.2015.12.001
- [ONLINE] View publication in Scopus
Mathematically guided approaches to distinguish models of periodic patterning
2015 - Published
Hiscock, T. W., Megason, S. G.
Development (Cambridge), vol. 142, no. 3, pp. 409-419
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/dev.107441
- [ONLINE] View publication in Scopus
Interplay of cell shape and division orientation promotes robust morphogenesis of developing epithelia
2014 - Published
Xiong, F., Ma, W., Hiscock, T. W., Mosaliganti, K. R., Tentner, A. R., Brakke, K. A., Rannou, N., Gelas, A., Souhait, L., Swinburne, I. A., Obholzer, N. D., Megason, S. G.
Cell, vol. 159, no. 2, pp. 415-427
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cell.2014.09.007
- [ONLINE] View publication in Scopus
Solar to electrical conversion via liquid crystal elastomers
2011 - Published
Hiscock, T., Warner, M., Palffy-Muhoray, P.
Journal of Applied Physics, vol. 109, no. 10, 104506
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1063/1.3581134
- [ONLINE] View publication in Scopus

Update

Biography

Research Overview

Research Areas

Accepting PhDs

Maths

Biomedical Sciences

Physics

Research Specialisms

Courses

Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals

Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs

A dot-stripe Turing model of joint patterning in the tetrapod limb

The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation

Navigating at night: fundamental limits on the sensitivity of radical pair magnetoreception under dim light

Identification of a regeneration-organizing cell in the Xenopus tail

Adapting machine-learning algorithms to design gene circuits

A single-cell molecular map of mouse gastrulation and early organogenesis

Identity and novelty in the avian syrinx

Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation

Feedback between tissue packing and neurogenesis in the zebrafish neural tube

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

On the Formation of Digits and Joints during Limb Development

Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies

Mathematically guided approaches to distinguish models of periodic patterning

Interplay of cell shape and division orientation promotes robust morphogenesis of developing epithelia

Solar to electrical conversion via liquid crystal elastomers