MBChB MRCP DM FRCPath
Chair in Applied Medicine (Clin)
- About
-
- Email Address
- m.a.vickers@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272401
- Office Address
1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.
External Memberships
Member of Royal College of Physicians
Fellow of Royal College of Pathologists
British Society for Haematology
- Research
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Research Overview
My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.
Knowledge Exchange
I have given talks about the use of convalescent plasma and T cells to treat COVID-19.
Collaborations
Prof. Alex Rowe, Edinburgh University.
Prof. Stuart Haslam, Imperial College London.
Prof. David Rees, King's College London.
Supervision
Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.
- Teaching
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Teaching Responsibilities
I organise, and deliver much of, the haematology training in the medical school. I remain an enthusiastic bedside teacher. I co-ordinated the third year medical degree 1997-2010.
- Publications
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Cellular turnover of normal gastrointestinal epithelium assessed by changes in telomeric: total DNA signal ratios
European Journal of Gastroenterology & Hepatology, vol. 15, no. 11, pp. 1195-1201Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/00042737-200311000-00008
Markers of endothelial activation and atherothrombosis in women with history of pre-eclampsia or gestational hypertension
Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1160/TH03-01-0053
Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma
Leukemia & Lymphoma, vol. 44, no. 12, pp. 2083-2088Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/1042819031000119316
Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen
Blood, vol. 100, no. 13, pp. 4529-4536Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2002-05-1383
Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review
Thrombosis and Haemostasis, vol. 87, no. 5, pp. 779-785Contributions to Journals: ArticlesEstimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors
Environmental and Molecular Mutagenesis, vol. 39, no. 4, pp. 333-341Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/em.10076
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
Cardiovascular Research, vol. 53, no. 4, pp. 1029-1034Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0008-6363(01)00534-X
The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 2001
QJM - Monthly Journal of the Association of Physicians, vol. 94, no. 11, pp. 643-655Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Assessment of mechanism of acquired skewed X inactivation by analysis of twins
Blood, vol. 97, no. 5, pp. 1274-1281Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.V97.5.1274
Plasma homocysteine concentrations in the acute and convalescent periods of atherothrombotic stroke
Stroke, vol. 32, no. 1, pp. 57-62Contributions to Journals: Articles