Professor Mark Vickers

Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

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  • Cellular turnover of normal gastrointestinal epithelium assessed by changes in telomeric: total DNA signal ratios

    Craig, W. L., McKinlay, A., Vickers, M. A.
    European Journal of Gastroenterology & Hepatology, vol. 15, no. 11, pp. 1195-1201
    Contributions to Journals: Articles
  • Markers of endothelial activation and atherothrombosis in women with history of pre-eclampsia or gestational hypertension

    Vickers, M. A., Ford, I., Morrison, R., Prescott, G. J., Watson, S., Hannaford, P. C., Smith, W. C. S., Campbell, D. M., Greaves, M.
    Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197
    Contributions to Journals: Articles
  • Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma

    Munro, L. R., Johnston, P. W., Canning, S. J., Vickers, M. A., Marshall, N. A., Hewitt, S. G., Tveita, K.
    Leukemia & Lymphoma, vol. 44, no. 12, pp. 2083-2088
    Contributions to Journals: Articles
  • Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen

    Hall, A. M., Ward, F. J., Vickers, M. A., Stott, L., Urbaniak, S., Barker, R. N.
    Blood, vol. 100, no. 13, pp. 4529-4536
    Contributions to Journals: Articles
  • Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review

    Morrison, E. R., Miedzybrodzka, Z. H., Campbell, D. M., Haites, N. E., Wilson, B., Watson, M., Greaves, M., Vickers, M. A.
    Thrombosis and Haemostasis, vol. 87, no. 5, pp. 779-785
    Contributions to Journals: Articles
  • Estimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors

    Vickers, M. A., Hoy, T., Kyoizumi, S., Hewitt, M., Lake, H., Boyse, J.
    Environmental and Molecular Mutagenesis, vol. 39, no. 4, pp. 333-341
    Contributions to Journals: Articles
  • Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

    Vickers, M. A., Green, F. R., Mayosi, B. M., Lathrop, M., Ratcliffe, P., Watkins, H., Keavney, B., Terry, C., Julier, C.
    Cardiovascular Research, vol. 53, no. 4, pp. 1029-1034
    Contributions to Journals: Articles
  • The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 2001

    Finlayson, N. D., Tomlinson, S., Weetman, A. P., Connell, J. M., Hill, A. V., Savage, C. O., Wiles, C. M., Williams, B., Ireland, J., Vallance, P., Whyte, M., Seckl, J. R., Jung, R., McKillop, J. H., Stout, R. W., Atkinson, A. B., Tomkin, G. H., Adgey, A. A., Axon, A. T., Beck, P., Eastwood, J. B., Fitzgerald, M., Godman, M. J., Heath, D. A., Kendall, M. J., MacGregor, G. A., Petrie, J. C., Ell, R. G., Allan, R. N., Barry, R. E., Boulton Jones, J. M., Evans, C. C., George, C. F., Heading, R. C., Jewell, D. P., Lazarus, J. H., Parker, A. C., Rawlins, M. D., Thurston, H., Cappuccio, F. P., Conlon, C. P., John, C. S., Dornhurst, A., Douglas, J. G., Elborn, J. S., El-Omar, E., Friedland, J. S., Gilks, C. F., Groves, R. W., Hall, A. S., Hawkey, C. J., Hillhouse, E., Hughes, J., Isaacs, J., Jardine, A. G., Jodrell, D. I., Jones, D. E., Monson, J. P., Price, P., Pugh, C. W., Ray, D. W., Santis, G., Satsangi, J., Scott, D. G., Scott, D. L., Vickers, M. A., Wardlaw, A.
    QJM - Monthly Journal of the Association of Physicians, vol. 94, no. 11, pp. 643-655
    Contributions to Journals: Articles
  • Assessment of mechanism of acquired skewed X inactivation by analysis of twins

    Vickers, M. A., McLeod, E., Wilson, I. J., Spector, T. D.
    Blood, vol. 97, no. 5, pp. 1274-1281
    Contributions to Journals: Articles
  • Plasma homocysteine concentrations in the acute and convalescent periods of atherothrombotic stroke

    Meiklejohn, D. J., Vickers, M. A., Dijkhuisen, R., Greaves, M.
    Stroke, vol. 32, no. 1, pp. 57-62
    Contributions to Journals: Articles
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