![Dr Fiona Murray Dr Fiona Murray](/img/200x200/staffpages/uploads/s04fm3/FMurray_1.jpg)
PhD Pharmacology
Senior Lecturer
- About
-
- Email Address
- fmurray@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437594
- Telephone Number
- +44 (0)1224 437391
- Office Address
Room 6.20, Institute of Medical Sciences
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I moved to the University of Aberdeen from the University of California, San Diego, where I initially did my postdoctoral training with Professor Paul Insel in the Department of Pharmacology before joining the Department of Medicine as junior faculty.
The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and B- and T-cell lymphomas, to uncover novel therapeutic targets. Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease. Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension. In addition, we have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension.Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension.
Qualifications
- BSc Pharmacology1998 - University of Aberdeen
- PhD Pharmacology2003 - University of Glasgow
Memberships and Affiliations
- Internal Memberships
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Active mentor in the University mentoring scheme
IMS Radiation Protection Supervisor
Athena SWAN committee member
Duly elected to serve as Senate members from the IMS
- External Memberships
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British Pharmacological Society Member
American Society for Pharmacology and Experimental Therapeutics Member
British Physiology Society Member
Committee member of the Scottish Cardiovascular forum
2009-2020 Editorial Board member of the British Journal of Pharmacology
2021-present Editor of Cellular Signalling
Prizes and Awards
AHA CPCC Cournand & Comroe Young Investigator Award Finalist,
TiP’s Young Pharmacologist of the Year Finalist,
ASPET/Molecular Pharmacology Division Postdoctoral Winner,
APS respiratory section Hermann Rahn Award
Diagnosis and treatment of chronic lymphocytic leukaemia (CLL): United States Patent 7846664
G-protein coupled receptor-associated diagnosis and drug targets: United States Patent 10107816
- Research
-
Research Overview
The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and B- and T-cell lymphomas, to uncover novel therapeutic targets. Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Pharmacology
- Physiology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
My current research focuses on the role of G protein-coupled receptors, in particular GPR75, that we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension. In addition I have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension.
Knowledge Exchange
SHMU radio and science demonstrations at summer community fairs, local preschools (Scott et al., Primary School Children can Take the Lead in Teaching Anatomy and Physiology to their Peers, HAPS, 2020) and Physiology Friday, Doors open day (University of Aberdeen). University of Aberdeen YouTube channel. LUNGEVITY: research driven activity for schools, community groups and open days to increase understanding of the role of the lung and highlight the effects of disease and smoking.
Collaborations
Elasmogen to develop antibodies for the treatment of age-related-macular-degeneration.
European Lead Factory (GPR75-screen).
Consultant for Enthorin
Funding and Grants
A NOVEL G PROTEIN-COUPLED RECEPTOR TARGET FOR METABOLIC SYNDROME. 02/02/21-01/02/22, TENOVUS SCOTLAND
REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR LEUKAEMIA AND LYMPHOMA. 1/5/21 – 30/4/22, FRIENDS OF ANCHOR
GPR75: A NOVEL DRUG TARGET AND BIOMARKER FOR AGE RELATED MACULAR DEGENERATION Crane, I. J., Collinson, J. M. & Murray, F. 3/09/19 → 2/09/20, TENOVUS SCOTLAND
EXPLOITING THE BODY'S ENDOCANNABINOID SYSTEM IN CHRONIC LYMPHOCYTIC LEUKAEMIA Vickers, M. A., Murray, F. & Pertwee, R. 1/10/18 → 30/09/19 £14,648, FRIENDS OF ANCHOR
REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR PULMONARY ARTERIAL HYPERTENSION Murray, F. 1/04/18 → 31/03/19, NHS GRAMPIAN
UNCOVERING THE PHARMACOLOGY OF GPR75: ROLE IN PULMONARY ARTERIAL HYPERTENSION. Murray, F. 1/03/17 → 1/07/19, WELLCOME TRUST
- Teaching
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Teaching Responsibilities
Course-coordinator - BM3501(Cardiovascular Physiology and Pharmacology)
Course-coordinator - MT5024/MT5524 (Molecular Pharmacology)
Lecturer - PA4005 (Molecular Pharmacology)
Lecturer - SM3002 (Frontiers of Biomedical Sciences)
Lecturer - BM5003 (Cardiovascular Health and Disease)
Non-course Teaching Responsibilities
Lab supervisor for undergraduates and postgraduates
- Publications
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Dynamic Endocannabinoid-mediated Neuromodulation of Retinal Circadian Circuitry
Ageing Research Reviews, vol. 99, 102401Contributions to Journals: ArticlesLoss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
Cell Metabolism, vol. 36, no. 5, pp. 1076-1087Contributions to Journals: ArticlesShifting our perspective on orphan G protein-coupled receptors
Nature Structural and Molecular Biology, vol. 31, no. 4, pp. 582-583Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1038/s41594-024-01270-1
- [ONLINE] View publication in Scopus
An endogenous inhibitor of angiogenesis downregulated by hypoxia in human aortic valve stenosis promotes disease pathogenesis
Journal of Molecular and Cellular Cardiology, vol. 174, pp. 25-37Contributions to Journals: ArticlesUsing Game of Thrones to teach physiology during lockdown and beyond.
Europhysiology 2022, pp. 263-264Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/apha.13875
Pupil-led biomedical lessons for primary school children: a pilot study
University of Aberdeen Annual Academic Development Symposium 2021Contributions to Conferences: PostersUsing Game of Thrones to teach neuroscience and neuropharmacology during lockdown
University of Aberdeen Annual Academic Development Symposium 2021Contributions to Conferences: PostersSex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension
Journal of the American Heart Association, vol. 10, no. 6, e019341Contributions to Journals: ArticlesNew Insights into Phosphodiesterase 1C as a Novel Target for Pulmonary Arterial Hypertension
2000 Meeting of the British-Pharmacological-Society (PHARMACOLOGY), pp. 424-425Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/bph.15316
Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 46, pp. 28763-28774Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.2004699117
Primary School Children can Take the Lead in Teaching Anatomy and Physiology to their Peers
Contributions to Journals: Conference ArticlesEndogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma
The Journal of Immunology, vol. 204, no. 6, pp. 1592-1597Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4049/jimmunol.1900690
- [ONLINE] View publication in Scopus
Deletion of caveolin scaffolding domain alters cancer cell migration
Cell Cycle, vol. 18, no. 11, pp. 1268-1280Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/15384101.2019.1618118
Student-created video resources can enhance medical science practical class assessment
Contributions to Conferences: PapersStudent perceptions of Objective Structured Practical Examination (OSPE) assessments
Pharmacology 2018Contributions to Conferences: PostersTwo Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen
Contributions to Specialist Publications: Featured ArticlesGPCRs in pulmonary arterial hypertension: tipping the balance
British Journal of Pharmacology, vol. 175, no. 15, pp. 3063-3079Contributions to Journals: Review articlesGPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets
Frontiers in Pharmacology, vol. 9, 431Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fphar.2018.00431
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10478/1/fphar_09_00431.pdf
Gender Bias in G Protein-Coupled Receptor Expression in Human Pulmonary Artery Smooth Muscle Cells
Experimental Biology, 1016.11Contributions to Journals: AbstractsNovel G protein-coupled receptors in Pancreatic Beta cells
Experimental Biology, 1052.1Contributions to Journals: AbstractsFunctional Magnetic Resonance Imaging for In Vivo Quantification of Pulmonary Hypertension in the Sugen 5416/hypoxia mouse
Experimental Physiology, vol. 102, no. 3, pp. 347–353Contributions to Journals: ArticlesAssessing the consequences of environmental impacts: variation in species responses has unpredictable functional effects
Marine Ecology Progress Series, vol. 583, pp. 35-47Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3354/meps12358
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/3/Murray_et_al.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/1/Murray_et_al_Appendix_v3.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/2/Murray_Fig1.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/6/Murray_Fig2.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/5/Murray_Fig3.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11448/4/Murray_Fig4.tif
The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
Cardiovascular Research, vol. 107, no. 4, pp. 546-555Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/cvr/cvv176
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4659/3/546.full.pdf
G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets
Molecular Pharmacology, vol. 88, no. 1, pp. 181-187Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1124/mol.115.098129
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
eLife, vol. 4, e07091Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.7554/eLife.07091
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6243/1/e07091_download.pdf
Quantitative Functional Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Arterial Hypertension
The FASEB Journal, vol. 29, no. 1 supplement 662.8Contributions to Journals: AbstractsCyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma
PNAS, vol. 112, no. 5, pp. 1529-1534Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1417972112
Interleukin 33 And Its Receptor, St2, Participate In The Development Of Pulmonary Arterial Hypertension In A Mouse Model
International Conference of the American-Thoracic-Society (ATS), A5284Contributions to Journals: AbstractsRenal phosphate wasting in the absence of adenylyl cyclase 6
Journal of the American Society of Nephrology, vol. 25, no. 12, pp. 2822-2834Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1681/ASN.2013101102
GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis
Nature Communications, vol. 5, 4451Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ncomms5451
G protein-coupled receptor expression and function in pulmonary artery smooth muscle cells: new targets in pulmonary arterial hypertension
The FASEB Journal, vol. 28, no. Suppl 1, 1090.3Contributions to Journals: AbstractsInterleukin-33 in pulmonary arterial hypertension: a role in disease pathogenesis?
The FASEB Journal, vol. 28, no. 1, 1090.4Contributions to Journals: AbstractsDeficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome
Human Molecular Genetics, vol. 22, no. 22, pp. 4502-15Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddt298
Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma
Expert Opinion on Therapeutic Targets, vol. 17, no. 8, pp. 937-49Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1517/14728222.2013.798304
HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?
PloS ONE, vol. 8, no. 5, pp. 1-11Contributions to Journals: ArticlesDivergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
The Journal of Clinical Investigation, vol. 122, no. 3, pp. 963-973Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1172/JCI59097
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (vol 471, pg 499, 2011)
Nature, vol. 474, no. 7349, pp. 114-114Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/nature10088
Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling
Journal of the American College of Cardiology, vol. 57, no. 22, pp. 2273-2283Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jacc.2010.12.032
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia
Nature, vol. 471, no. 7339, pp. 499-503Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/nature09884
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia
PNAS, vol. 105, no. 49, pp. 19532-19537Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.0806152105