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The Institute of Medical Sciences

Dr Ian Fleming

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Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

About
Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition
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Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

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  • A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions

    Thompson, S., Zhang, Q., Onega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, J. H., Passchier, J., O'Hagan, D.
    Angewandte Chemie International Edition, vol. 53, no. 34, pp. 8913-8918
    Contributions to Journals: Articles

  • Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α

    Fleming, I. N., Andriu, A., Smith, T. A. D.
    Breast Cancer Research and Treatment, vol. 144, no. 4, pp. 241-248
    Contributions to Journals: Articles

  • Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles

    Testa, A., Piras, M., Hickey, M. J., Fleming, I. N., Bushby, N., Lenz, E., Elmore, C. S., Zanda, M.
    Synlett, vol. 25, no. 07, pp. 1019-1025
    Contributions to Journals: Articles

  • Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

    Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M., Petty, R. D.
    British Journal of Cancer, vol. 110, no. 6, pp. 1525-1534
    Contributions to Journals: Articles

  • Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase

    Smith, T. A. D., Zanda, M., Fleming, I. N.
    Nuclear Medicine and Biology, vol. 40, no. 6, pp. 858-864
    Contributions to Journals: Articles

  • Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor

    Dall'angelo, S., Zhang, Q., Fleming, I. N., Piras, M., Schweiger, L. F., O'Hagan, D., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558
    Contributions to Journals: Articles

  • Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR detectable phosphomonesters

    Smith, T. A. D., Appleyard, M. V. C. L., Sharp, S., Fleming, I. N., Murray, K., Thompson, A. M.
    Cancer Chemotherapy and Pharmacology, vol. 71, no. 2, pp. 473-480
    Contributions to Journals: Articles

  • Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers

    Fleming, I. N., Whelan, M., Baxendale, R., Gilbert, F. J., Matthews, P. P., Aigbirhio, F. I.
    Nuclear Medicine Communications, vol. 33, no. 9, pp. 899-906
    Contributions to Journals: Articles

  • Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

    Aboagye, E. O., Gilbert, F. J., Fleming, I. N., Beer, A. J., Cunningham, V. J., Marsden, P. K., Visvikis, D., Gee, A. D., Groves, A. M., Kenny, L. M., Cook, G. J., Kinahan, P. E., Myers, M., Clarke, L., Experimental Cancer Medicine Centre 13 Imaging Network Group
    European Radiology, vol. 22, no. 7, pp. 1465-1478
    Contributions to Journals: Articles

  • Positron emission tomography oncology research in the UK: a comparison with USA and Europe

    Fleming, I. N., Regel, S. J., Pike, L. C., Marsden, P. K., Gilbert, F. J.
    Nuclear Medicine Communications, vol. 33, no. 4, pp. 341-348
    Contributions to Journals: Articles
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