BSc MSc PhD MIPEM
Honorary Professor
- About
-
- Email Address
- r.staff@abdn.ac.uk
- Office Address
Nuclear Medicine ARI Foresterhill Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Roger Staff was born in London and studied physics at UEA. He moved to Aberdeen in 1988 and completed his PhD in medical physics in 1994. He has worked for the NHS since 1991 and currently leads the clinical physics imaging team at NHS-Grampian. His other interests include Intelligence and social mobility.
- Research
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Research Overview
(Since 1999) founding member of the Aberdeen 1921 & 1936 birth cohort study group with three critical responsibilities for (1) hypothesis generation and hypothesis testing; (2) brain imaging and image analysis; (3) Advance data modelling of complex databases; (Since 2003 with Taurx) the imaging the effects tau aggregation inhibition and the use of surrogate imaging measures in drug development; (Since 2008) the development of structural and temporal (fMRI) complexity measures for use in ageing and neurodegenerative disease; (Since 2012) The prognostic value of automated analysis of sequential retinal images in diabetic retinopathy. The use of external quality assurance programs in diabetic retinopathy.
- Publications
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Page 1 of 1 Results 1 to 90 of 90
Impact of Different Mammography Systems on Artificial Intelligence Performance in Breast Cancer Screening
Radiology: Artificial Intelligence, vol. 5, no. 3, e220146Contributions to Journals: ArticlesAI in breast screening mammography: breast screening readers' perspectives
Insights into Imaging, vol. 13, no. 1, 186Contributions to Journals: ArticlesThe Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery
Clinical Breast Cancer, vol. 22, no. 5, pp. e674-e679Contributions to Journals: ArticlesSexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study
Scientific Reports, vol. 12, 11025Contributions to Journals: ArticlesCognitive Test Scores and Progressive Cognitive Decline in the Aberdeen 1921 and 1936 Birth Cohorts
Brain Sciences, vol. 12, no. 3, 318Contributions to Journals: ArticlesDegeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
Brain Communications, vol. 3, no. 4, fcab241Contributions to Journals: ArticlesLong-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023Contributions to Journals: ArticlesScreening participants’ attitudes to the introduction of artificial intelligence in breast screening
Journal of Medical Screening, vol. 28, no. 3, pp. 221-222Contributions to Journals: LettersIQ tests: are humans getting smarter?
Contributions to Specialist PublicationsImprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life
Scientific Reports, vol. 11, 943Contributions to Journals: ArticlesConcentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesAspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing
Maturitas, vol. 133, pp. 49-53Contributions to Journals: ArticlesKlotho gene polymorphism, brain structure and cognition in early-life development
Brain Imaging and Behavior, vol. 14, pp. 213-225Contributions to Journals: ArticlesMotion during Acquisition is Associated with fMRI Brain Entropy
IEEE journal of biomedical and health informatics, vol. 24, no. 2, pp. 586-593Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1109/JBHI.2019.2907189
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13672/1/deVries_etal_IEEE_Motion_During_VOR.pdf
- [ONLINE] View publication in Mendeley
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/motion-during-acquisition-is-associated-with-fmri-brain-entropy(29372db1-d432-4fbd-a73a-468872424e30).html
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesCortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
International Journal of Neural Systems, vol. 29, no. 6, 1850055Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11981/3/Cortical_Thickness_and_Surface_Area_Networks_in_Healthy_Aging_Alzheimer_s_Disease_and_Behavioral_Variant_Fronto_Temporal_Dementia.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Does problem-solving really protect against cognitive decline in old age?
The ConversationContributions to Specialist Publications: ArticlesIntellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture): Longitudinal, prospective study
BMJ (Online), vol. 363, k4925Contributions to Journals: ArticlesThe influence of childhood intelligence, social class, education and social mobility on memory and memory decline in late life
Age and Ageing, vol. 47, no. 6, pp. 847-852Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afy111
- [ONLINE] View publication in Scopus
Distribution of retinal microaneurysms in diabetic retinopathy using automated retinal image analysis
Diabetic Medicine, vol. 35, no. S1, pp. 182Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.53_13571
Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing
Age and Ageing, vol. 47, no. 1, pp. 95-100Contributions to Journals: ArticlesLife-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review
Aging & Mental Health, vol. 22, no. 8, pp. 915-926Contributions to Journals: ArticlesPotential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457Contributions to Journals: Articles- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
6th Cambridge Neuroscience SymposiumContributions to Conferences: AbstractsChildhood intelligence and personality traits neuroticism and openness contributes to social mobility: A study in the Aberdeen 1936 Birth Cohort
Personality and Individual Differences, vol. 114, pp. 206-212Contributions to Journals: ArticlesKlotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936
Neurobiology of Aging, vol. 55, pp. 91-98Contributions to Journals: ArticlesSexual dimorphism in changes of cortical complexity associated with cognitive decline in late life
Alzheimer's Research UKContributions to Conferences: AbstractsA brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)
Neuroimage, vol. 144, no. Part B, pp. 299–304Contributions to Journals: ArticlesDistinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study
Alzheimer Research UK (2017)Contributions to Conferences: AbstractsEfficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
The Lancet, vol. 388, no. 10062, pp. 2873-2884Contributions to Journals: ArticlesLate-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936)
Age and Ageing, vol. 45, no. 4, pp. 486-493Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afw061
Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life
Archives of Gerontology and Geriatrics, vol. 63, pp. 49-54Contributions to Journals: ArticlesCerebral correlates of cognitive reserve
Psychiatry Research, vol. 247, pp. 65-70Contributions to Journals: ArticlesNeural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis
SINAPSE Annual Scientific Meeting (2016)Contributions to Conferences: AbstractsQUALITY ASSURANCE IN DIABETIC RETINAL SCREENING IN SOUTH AFRICA: A BASELINE AND FOLLOW-UP STUDY
26th Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec), pp. E102-E102Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.5301/ejo.5000799
Phenothiazine compounds for treating mild cognitive impairment
Patents: PatentsFuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span
Medical Engineering & Physics, vol. 37, no. 11, pp. 1082-1090Contributions to Journals: ArticlesA longitudinal study of cognitive and hippocampal ageing in late life
British Neuroscience Association, 2015 Festival of NeuroscienceContributions to Conferences: AbstractsMapping the cortical complexity and cognitive decline in late life
Alzheimer's research UK 2015Contributions to Conferences: AbstractsTau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-142874
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4205/1/fulltext.pdf
Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort
Neuroimage, vol. 100, pp. 558-563Contributions to Journals: ArticlesImproving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study
British Journal of Ophthalmology, vol. 98, no. 8, pp. 1042-1049Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bjophthalmol-2013-304338
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4265/1/ISMO_manuscript.doc
A longitudinal study of human brain complexity and cognitive decline in ageing
Organization of Human Brain Mapping meeting (OHBM)Contributions to Conferences: AbstractsNonlinear complexity analysis of brain FMRI signals in schizophrenia
PloS ONE, vol. 9, no. 5, e95146Contributions to Journals: ArticlesEarly Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study
PloS ONE, vol. 9, no. 2, e88969Contributions to Journals: ArticlesHomocysteine, antioxidant micronutrients and late onset dementia
European Journal of Nutrition, vol. 53, no. 1, pp. 277-285Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00394-013-0526-6
Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion location
Depression and Anxiety, vol. 30, no. 1, pp. 77-84Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/da.22022
Genetic and environmental factors in late onset dementia: possible role for early parental death
International Journal of Geriatric Psychiatry, vol. 28, no. 1, pp. 75-81Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/gps.3792
Brain structural complexity and life course cognitive change
Neuroimage, vol. 61, no. 3, pp. 694-701Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.neuroimage.2012.03.088
Do brain image databanks support understanding of normal ageing brain structure?: A systematic review
European Radiology, vol. 22, no. 7, pp. 1385-1394Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00330-012-2392-7
Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia
Journal of Alzheimer's Disease, vol. 30, no. 2, pp. 253-261Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-2012-110935
Childhood socioeconomic status and adult brain size: Childhood socioeconomic status influences adult hippocampal size
Annals of Neurology, vol. 71, no. 5, pp. 653-660Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ana.22631
Brain lesions, hypertension and cognitive aging in the 1921 and 1936 Aberdeen birth cohorts
Age, vol. 34, no. 2, pp. 451-459Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s11357-011-9233-5
The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases
Brain, vol. 134, no. 12, pp. 3687-3696Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/brain/awr259
Inter-individual differences in fMRI entropy measurements in old age
IEEE Transactions on Biomedical Engineering, vol. 58, no. 11, pp. 3206-3214Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1109/TBME.2011.2164793
Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease
Behavioural Brain Research, vol. 222, no. 2, pp. 375-379Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2011.04.003
Childhood intelligence and brain white matter hyperintensities predict fluid intelligence age 78-81 years: a 1921 Aberdeen birth cohort study
Age and Ageing, vol. 40, no. 5, pp. 562-567Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afr065
How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability
Maturitas, vol. 69, no. 4, pp. 365-372Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.maturitas.2011.05.010
Cerebellar brain volume accounts for variance in cognitive performance in older adults
Cortex, vol. 47, no. 4, pp. 441-450Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cortex.2010.01.001
The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease
Neuroscience & Medicine, vol. 2, no. 1, pp. 6-13Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4236/nm.2011.21002
The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature
Breast Cancer Research and Treatment, vol. 123, no. 1, pp. 281-290Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10549-010-0771-9
Brain volume and survival from age 78 to 85: the contribution of Alzheimer-type magnetic resonance imaging findings
Journal of the American Geriatrics Society, vol. 58, no. 4, pp. 688-695Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1532-5415.2010.02765.x
Approximate entropy fMRI differences associated with cognitive decline
Neuroimage, vol. 47, no. Supplement 1, pp. S102Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S1053-8119(09)70883-3
Shape analysis of 123I-N-ω-fluoropropyl-2-β-carbomethoxy-3β-(4-iodophenyl) nortropane single-photon emission computed tomography images in the assessment of patients with parkinsonian syndromes
Nuclear Medicine Communications, vol. 30, no. 3, pp. 194-201Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/MNM.0b013e328314b863
Monitoring primary breast cancer throughout chemotherapy using FDG-PET
Breast Cancer Research and Treatment, vol. 102, no. 1, pp. 75-84Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/S10549-006-9316-7
Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration
Annals of Oncology, vol. 17, pp. 1393-1398Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/annonc/mdl136
Generality and specificity in cognitive aging: a volumetric brain analysis
Neuroimage, vol. 30, no. 4, pp. 1433-1440Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.neuroimage.2005.11.004
A55 A rCBF study of hallucinations in dementia.
Nuclear Medicine Communications, vol. 27, no. 3, 295Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1097/00006231-200603000-00066
Predicting response using MRI enhancement characteristics when response is determined by using change in enhancement pattern
Breast Cancer Research and Treatment, vol. 97, pp. 111-111Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1007/s10549-005-9096-5
Brain white matter hyperintensities: Relative importance of different vascular risk factors in non-demented elderly people
Radiology, vol. 237, no. 1, pp. 251-257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1148/radiol.2371041496
The use of the Levenberg-Marquardt curve-fitting algorithm in pharmacokinetic modelling of DCE-MRI data
Physics in Medicine and Biology, vol. 50, no. 9, pp. N85-N92Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1088/0031-9155/50/9/N02
FPCIT.net: a web based archive for use with 123I ioflupane
Nuclear Medicine Communications, vol. 26, P38Contributions to Journals: AbstractsThe relationship between vascular and metabolic characteristics of primary breast tumours
European Radiology, vol. 14, no. 11, pp. 2038-2045Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00330-004-2454-6
The correlation between FDG PET and the vascular characteristic of breast tumours measured using dynamic contrast enhanced MRI
European Journal of Nuclear Medicine and Molecular Imaging, vol. 31, no. Suppl., pp. S231Contributions to Journals: ArticlesWhat provides cerebral reserve?
Brain, vol. 127, no. 5, pp. 1191-1199Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/brain/awh144
The effects of renal variation upon measurements of perfusion and leakage volume in breast tumours
Physics in Medicine and Biology, vol. 49, no. 10, pp. 2041-2051Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1088/0031-9155/49/10/014
Brain white matter lesions detected by magnetic resonance imaging are associated with balance and gait speed
Journal of Neurology, Neurosurgery & Psychiatry, vol. 74, no. 1, pp. 94-98Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jnnp.74.1.94
Advanced imaging: Magnetic resonance imaging in implant dentistry - A review
Clinical Oral Implants Research, vol. 14, pp. 18-27Contributions to Journals: Literature ReviewsCerebral white matter abnormalities and lifetime cognitive change: A 67 year follow up of the Scottish Mental Survey of 1932
Psychology and Aging, vol. 18, no. 1, pp. 140-148Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1037/0882-7974.18.1.140
Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people
Neuroscience Letters, vol. 341, no. 3, pp. 173-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0304-3940(02)01452-0
Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer's disease
Neuroreport, vol. 13, no. 1, pp. 83-87Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/00001756-200201210-00020
Dynamic contrast enhanced MRI of the axilla in women with breast cancer: comparison with pathology of excised nodes
British Journal of Radiology, vol. 75, no. 891, pp. 220-228Contributions to Journals: ArticlesNeuropsychologic correlates of brain white matter lesions depicted on MR images: 1921 Aberdeen Birth Cohort
Radiology, vol. 221, no. 1, pp. 51-55Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1148/RADIOL.2211010086
The use of SPAMM to assess spatial distortion due to static field inhomogeneity in dental MRI
Physics in Medicine and Biology, vol. 46, no. 5, pp. 1357-1367Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1088/0031-9155/46/5/302
HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion: Comparison using statistical parametric mapping
Journal of Nuclear Medicine, vol. 41, no. 9, pp. 1451-1455Contributions to Journals: ArticlesLanguage mapping in a left handed patient with glioma using H215O positron emission tomography
Neuroimage, vol. 11, no. 5 Suppl. , pp. S321Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S1053-8119(00)91253-9
Assessment of maxillary sinus volume for the sinus lift operation by three-dimensional magnetic resonance imaging
Dento Maxillo Facial Radiology, vol. 29, pp. 154-158Contributions to Journals: ArticlesChanges in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy
Nuclear Medicine Communications, vol. 21, no. 1, pp. 37-41Contributions to Journals: ArticlesAssessment of the sinus lift operation by magnetic resonance imaging
British Journal of Oral and Maxillofacial Surgery, vol. 37, no. 4, pp. 285-289Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1054/bjom.1999.0073
Accuracy of T1 measurement in dynamic contrast-enhanced breast MRI using two- and three-dimensional variable flip angle fast low-angle shot
Journal of Magnetic Resonance Imaging, vol. 9, no. 2, pp. 163-171Contributions to Journals: Articles