MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
-
- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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Page 1 of 1 Results 1 to 91 of 91
Recognition and control of neutrophil extracellular trap formation by MICL
Nature, vol. 633, no. 8029, pp. 442-450Contributions to Journals: ArticlesDisentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Osteoarthritis and CartilageContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2024.07.006
Vascular disease persistence in giant cell arteritis: are stromal cells neglected?
Annals of the Rheumatic DiseasesContributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1136/ard-2023-225270
Osteoarthritis year in review 2023: Biology
Osteoarthritis and Cartilage, vol. 32, no. 2, pp. 148-158Contributions to Journals: ArticlesBMP signalling: A significant player and therapeutic target for osteoarthritis
Osteoarthritis and Cartilage, vol. 31, no. 11, pp. 1454-1468Contributions to Journals: ArticlesTowards disease modification in osteoarthritis
Osteoarthritis and Cartilage, vol. 31, no. 9, pp. 1154-1155Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2023.05.002
Spatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Journal of Bone and Mineral Research, vol. 38, no. 5, pp. 792-807Contributions to Journals: ArticlesTaxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Annals of the Rheumatic Diseases, vol. 82, no. 3, pp. 428-437Contributions to Journals: ArticlesCellular therapy and tissue engineering for cartilage repair
Osteoarthritis and Cartilage, vol. 30, no. 12, pp. 1547-1560Contributions to Journals: Review articlesA cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise
Cell Stem Cell, vol. 29, no. 4, pp. 528-544.e9Contributions to Journals: ArticlesTargeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis
Annals of the Rheumatic Diseases, vol. 81, no. 2, pp. 214-224Contributions to Journals: ArticlesHuman Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model
Cells, vol. 10, no. 8, 1999Contributions to Journals: ArticlesThe Role of Siglec-9 in ANCA-associated Vasculitis
European Congress of Immunology 2021, pp. 94Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1002/eji.202170200
Evaluation of Adjunctive Mycophenolate for Large Vessel Giant Cell Arteritis
Rheumatology Advances in Practice, vol. 4, no. 2, rkaa069Contributions to Journals: ArticlesIdentification of the skeletal progenitor cells forming osteophytes in osteoarthritis
Annals of the Rheumatic Diseases, vol. 79, no. 12, pp. 1625-1634Contributions to Journals: ArticlesAgrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Science translational medicine, vol. 12, no. 559, eaax9086Contributions to Journals: ArticlesStem and progenitor cells in synovium
Encyclopedia of Bone Biology. Zaidi, M. (ed.). Elsevier, pp. 96-108, 13 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-801238-3.11160-2
- [ONLINE] View publication in Scopus
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
Scientific Reports, vol. 10, 157Contributions to Journals: ArticlesStratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis
Rheumatology Advances in Practice, vol. 4, no. 2, rkaa024Contributions to Journals: ArticlesThe burden of metabolic syndrome on osteoarthritic joints
Arthritis Research & Therapy, vol. 21, 289Contributions to Journals: Review articlesImmunostaining of Skeletal Tissues
Methods in molecular biology (Clifton, N.J.), vol. 1914, pp. 437-450Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-8997-3_25
Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair
Journal of Orthopaedic Research, vol. 37, no. 1, pp. 12-22Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1002/jor.24136
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Stem Cell-based Therapeutic Strategies for Cartilage Defects and Osteoarthritis
Current Opinion in Pharmacology, vol. 40, pp. 74-80Contributions to Journals: Review articlesAdipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
Molecular Metabolism, vol. 10, pp. 55-65Contributions to Journals: ArticlesThe potential role of adult stem cells in the management of the rheumatic diseases
Therapeutic advances in musculoskeletal disease, vol. 9, no. 7, pp. 165-179Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1177/1759720X17704639
Joint morphogenetic cells in the adult mammalian synovium
Nature Communications, vol. 8, 15040Contributions to Journals: ArticlesMesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?
Current Opinion in Rheumatology, vol. 29, no. 2, pp. 201-207Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1097/BOR.0000000000000370
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10119/1/Ansboro_et_al_revised.pdf
- [ONLINE] View publication in Scopus
Regenerative Medicine and Tissue Engineering
Kelley and Firestein's Textbook of Rheumatology. Tenth Edition edition. Elsevier, pp. 90-105.e4Chapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-323-31696-5.00007-3
- [ONLINE] View publication in Scopus
Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury
Arthritis Research & Therapy, vol. 18, 166Contributions to Journals: ArticlesMICL controls inflammation in rheumatoid arthritis
Annals of the Rheumatic Diseases, vol. 75, no. 7, pp. 1386-1391Contributions to Journals: ArticlesA homeostatic function of CXCR2 signalling in articular cartilage
Annals of the Rheumatic Diseases, vol. 74, no. 12, pp. 2207-2215Contributions to Journals: ArticlesYes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
Arthritis Research & Therapy, vol. 17, 147Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0639-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7388/1/s13075_015_0639_9.pdf
Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
Arthritis Research & Therapy, vol. 17, 113Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0634-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4800/1/s13075_015_0634_1.pdf
Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis
Rheumatology, vol. 54, no. 2, pp. 210-218Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/keu377
Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice
Cartilage, vol. 5, no. 4, pp. 231-240Contributions to Journals: Articles- [ONLINE] http://car.sagepub.com/content/5/4/231.full
- [ONLINE] DOI: https://doi.org/10.1177/1947603514541274
The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation
Cancer Cell, vol. 26, no. 2, pp. 273-287Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ccr.2014.05.029
In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum
European Cells & Materials, vol. 27, pp. 185-195Contributions to Journals: ArticlesProspective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency.
Rheumatology, vol. 52, no. 10, pp. 1758-1768Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/ket205
- [ONLINE] View publication in Scopus
Cell-based Approaches to Joint Surface Repair: A Research Perspective
Osteoarthritis and Cartilage, vol. 21, no. 7, pp. 892-900Contributions to Journals: Review articlesMesenchymal stem cell niches in joint health and disease
European Cells & Materials, vol. 26, no. suppl. 3, pp. 5Contributions to Journals: Articles- [ONLINE] View publication in Scopus
The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells
Journal of Cell Science, vol. 125, no. 24, pp. 6009-6019Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jcs.109546
Immunostaining of skeletal tissues
Methods in Molecular Biology, vol. 816, no. 4, pp. 321-334Contributions to Journals: ArticlesDirected migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field
European Cells & Materials, vol. 22, no. -, pp. 344-358Contributions to Journals: ArticlesRole of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases
Arthritis & Rheumatism, vol. 63, no. 9, pp. 2547-2557Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.30474
Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo
Arthritis & Rheumatism, vol. 63, no. 5, pp. 1289-1300Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.30234
Future dentistry: cell therapy meets tooth and periodontal repair and regeneration
Journal of Cellular and Molecular Medicine, vol. 15, no. 5, pp. 1054-1065Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1582-4934.2010.01251.x
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
Journal of Cell Biology, vol. 193, no. 3, pp. 551-564Contributions to Journals: ArticlesDual origin of mesenchymal stem cells contributing to organ growth and repair
PNAS, vol. 108, no. 16, pp. 6503-6508Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1015449108
Mesenchymal differentiation propensity of a human embryonic stem cell line
Cell Proliferation, vol. 44, no. 2, pp. 120-127Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2184.2011.00744.x
Prospects of stem cell therapy in osteoarthritis
Regenerative Medicine, vol. 6, no. 3, pp. 351-366Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2217/rme.11.21
Mesenchymal stem cells from development to postnatal joint homeostasis, aging, and disease
Birth Defects Research. Part C, Embryo Today: Reviews, vol. 90, no. 4, pp. 257-271Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bdrc.20189
The regulation of differentiation in mesenchymal stem cells
Human Gene Therapy, vol. 21, no. 10, pp. 1226-1238Contributions to Journals: ArticlesMesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches
European Cells & Materials, vol. 20, pp. 121-133Contributions to Journals: ArticlesHuman single-chain variable fragment that specifically targets arthritic cartilage
Arthritis & Rheumatism, vol. 62, no. 4, pp. 1007-1016Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.27346
Yap is a novel regulator of C2C12 myogenesis
Biochemical and Biophysical Research Communications, vol. 393, no. 4, pp. 619-624Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbrc.2010.02.034
Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table
Stem Cells and Development, vol. 19, no. 2, pp. 143-154Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1089/scd.2009.0404
Distinct mesenchymal progenitor cell subsets in the adult human synovium
Rheumatology, vol. 48, no. 9, pp. 1057-1064Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/kep192
Mesenchymal stem cells find their niches in skeletal regenerative medicine
European Cells and Materials, vol. 18, no. SUPPL. 1Contributions to Journals: Articles- [ONLINE] View publication in Scopus
A novel in vivo murine model of cartilage regeneration: Age and strain-dependent outcome after joint surface injury
Osteoarthritis and Cartilage, vol. 17, no. 6, pp. 695-704Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2008.11.003
Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources
Differentiation: Research in Biological Diversity, vol. 76, no. 9, pp. 946-957Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1432-0436.2008.00279.x
A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination
Developmental Biology, vol. 320, no. 1, pp. 39-48Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.12.001
The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing organs: The rodent incisor as a model
Developmental Biology, vol. 320, no. 1, pp. 256-266Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.05.530
Stem cells for tooth engineering
European Cells & Materials, vol. 16, no. 1, pp. 1-9Contributions to Journals: ArticlesIdentification of the molecular response of articular cartilage to injury, by microarray screening
Arthritis & Rheumatism, vol. 58, no. 5, pp. 1410-1421Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23444
Apoptosis in developmental and repair-related human tooth remodeling: a view from the inside
Experimental Cell Research, vol. 314, no. 4, pp. 869-877Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.11.001
Cell therapy: a challenge in modern medicine
3rd International Meeting on Medical Engineering and Therapy, pp. 11-17Contributions to Journals: Special IssuesA biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells
Arthritis & Rheumatism, vol. 58, no. 1, pp. 240-250Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23143
Mesenchymal stem cells in rheumatology: A regenerative approach to joint repair
Clinical Science, vol. 113, no. 8, pp. 339-348Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/CS20070126
Stem cell niches in mammals
Experimental Cell Research, vol. 313, no. 16, pp. 3377-3385Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.07.027
Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development
Arthritis & Rheumatism, vol. 56, no. 3, pp. 714-721Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22440
Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis
Arthritis & Rheumatism, vol. 56, no. 2, pp. 489-497Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22372
Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Arthritis Research & Therapy, vol. 9, no. 1, pp. 301Contributions to Journals: ArticlesEfficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells
Stem Cells, vol. 24, no. 4, pp. 896-907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1634/stemcells.2003-0106
Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis
Arthritis & Rheumatism, vol. 54, no. 4, pp. 1209-1221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ART.21753
Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
Arthritis Research & Therapy, vol. 8, no. 5, pp. R139Contributions to Journals: ArticlesReparative medicine: from tissue engineering to joint surface regeneration
Regenerative Medicine, vol. 1, no. 1, pp. 59-69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2217/17460751.1.1.59
Increased Bcl-2/p53 ratio in human osteoarthritic cartilage: a possible role in regulation of chondrocyte metabolism
Annals of the Rheumatic Diseases, vol. 64, no. 2, pp. 217-221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.2004.022590
Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo
Experimental Cell Research, vol. 287, no. 1, pp. 16-27Contributions to Journals: ArticlesIn vitro growth rate of fibroblast-like synovial cells is reduced by methotrexate treatment
Annals of the Rheumatic Diseases, vol. 62, no. 6, pp. 568-571Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.62.6.568
Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane
Archives of Histology and Cytology, vol. 66, no. 2, pp. 145-153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1679/aohc.66.145
Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats
Haemophilia, vol. 9, no. 1, pp. 94-103Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2516.2003.00709.x
Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation
Journal of Orthopaedic Research, vol. 21, no. 1, pp. 123-131Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0736-0266(02)00090-6
Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes
Rheumatology, vol. 41, no. 12, pp. 1413-1418Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/41.12.1413
Skeletal tissue engineering: opportunities and challenges
Best Practice & Research Clinical Rheumatology, vol. 15, no. 5, pp. 759-769Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1053/berh.2001.0192
Multipotent mesenchymal stem cells from adult human synovial membrane
Arthritis & Rheumatism, vol. 44, no. 8, pp. 1928-1942Contributions to Journals: ArticlesMolecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
Arthritis & Rheumatism, vol. 44, no. 7, pp. 1608-1619Contributions to Journals: ArticlesHuman periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age
Arthritis & Rheumatism, vol. 44, no. 1, pp. 85-95Contributions to Journals: ArticlesInterleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes
Clinical and Experimental Rheumatology, vol. 19, no. 2, pp. 139-145Contributions to Journals: ArticlesCoexisting psoriatic arthritis, gout, and chondrocalcinosis
Scandinavian Journal of Rheumatology, vol. 27, no. 4, pp. 306-309Contributions to Journals: ArticlesIsolated thrombocytopenia associated with low dose methotrexate therapy
Clinical Rheumatology, vol. 16, no. 4, pp. 429-430Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/BF02242465
Anti-bacterial antibodies in Behçet's disease
Clinical and Experimental Rheumatology, vol. 15, no. 4, pp. 451-452Contributions to Journals: Articles