MB ChB MRCP(UK)
Honorary Chair
- About
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- Email Address
- r.l.soiza@abdn.ac.uk
- Office Address
c/o Ageing Clinical & Experimental Research, University of Aberdeen, Room 1:128, Polwarth Building, Aberdeen AB25 2ZD United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Edinburgh University in 2000 and became a Member of the Royal College of Physicians in 2003. Later that year, I joined the North of Scotland training programme as a Specialist Registrar in Geriatric Medicine and General Internal Medicine. In 2006, I joined the University of Aberdeen as Clinical Lecturer in Elderly Medicine.
I was a Consultant Geriatrician with NHS Grampian from 2008 to 2018, before joining the General Medicine Department at Aberdeen Royal Infirmary, returning to Geriatric Medicine in 2023. I have held numerous roles in postgraduate medical training, including Training Programme Director for Core Medical Training and Geriatric Medicine and serving as Associate Postgraduate Dean from 2015-2017.
I was awarded an NRS Career Researcher Fellowship in 2012. Having previous held roles of Honorary Senior Lecturer and Honorary Reader, I was awarded an Honorary Chair in February 2024. I am the Editor-in-Chief of Age & Ageing.
External Memberships
- Consultant Physician, NHS Grampian
- Editor in Chief, Age & Ageing 2024- (previously Senior Editor 2022-4, Associate Editor 2020-2)
- Associate Editor, Therapeutic Advances in Drug Safety 2010-, Geriatric Pharmacology 2023-, SAGE Open Medicine 2012-,
- Editorial Board Member, American Journal of Cardiovascular Disease 2011-, BMC Health Services Research 2014-
- Growing Older in Scotland Report, Reference Group Member
- Reviewer, for numerous international medical journals and grant-awarding bodies including MRC, CSO, NIHR, Research Council of Norway, South African Medical Research Council and Italian Ministry of Education, Universities & Research
Other Recent Roles
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Associate Postgraduate Dean (Medicine), NES, 1st Feb 2015 – 31st Aug 2017
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NRS Career Research Fellow 2012-5
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Treasurer, Scottish Society of Physicians, 2014-8
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Executive Committee Member, Scottish Society of Physicians, 2012-8
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Scottish Intercollegiate Guideline Network (SIGN), Delirium Guideline Development Group Member 2016-9, Dementia Guideline Group Member 2020-
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Chair, Organising Committee, RCPE Geriatric Medicine Symposium 2019
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Faculty Member, Faculty Development Alliance (formerly SCOTS Supervisor Training Courses), 2010-7
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Electives Adviser, University of Aberdeen Medical School, 2010-8
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Training Programme Director, North of Scotland Deanery
Core Medical Training 2010-3
Geriatric Medicine 2011-5
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Educational Supervisor, Foundation Programme, GP and Specialty Registrars, 2008-
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Chair, Medical Specialties Training Committee, North of Scotland Deanery 2013-2015
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Member, RCP/BGS Geriatric Medicine Specialty Certificate Exam (SCE) Question Writing Group, 2009-14
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Advisory Board Member, Otsuka Pharmaceuticals (UK), 2010-12
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External Examiner, MSc (Hons) research theses, Dundee University and Flinders University 2012-6
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Clinical Supervisor, Physician Associate course, University of Aberdeen 2013-5
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‘Hospital to Home’ National Project Advisory Group Member, Institute for Research and Innovation in Social Services (IRISS), 2013-6
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Expert panellist, for a number of Delphi expert panels, e.g. for the FORTA, OPERAM and PERFECTED clinical trials
- Research
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Research Overview
I am interested in all aspects of health and disease in old age. My chief interests are hyponatraemia in older people and clinical pharmacology in old age. More recently, I have been working on COVID-19 therapy trials, and leading on vaccine trials. I have also researched polypharmacy, whole body vibration exercise, vascular ageing and cognitive ageing. I run clinical trials in older people but have wide experience in epidemiological and mechanistic studies, as well as systematic reviews.
Current Research
I am the Aberdeen Principal Investigator for the NOVAVAX, MODERNA P-305 (omicron), Medicago, BiCARB, K-SWAY, LACE, RAINDROP and SENATOR randomised controlled trials.
I have an ongoing interest in hyponatraemia, most recently investigating the causes of hyponatraemia after head injury.
I also led Wave 4 of the Aberdeen 1936 Birth Cohort (ABC36) Study, a longitudinal cohort study of cognitive ageing.
Supervision
I have supervised numerous undergraduate and postgraduate students from medical elective students to PhD candidates.
Funding and Grants
Current Grants
- 'Widening Access to Trials in Care Homes (WATCH)' RL Soiza, Vaccine Innovation Fund 24/005, £299,792
- ‘An evidence synthesis suite to inform a a future randomised trial of reducing anticholinergic related harm in older adults’, PK Myint, RL Soiza et al (6 co-investigators), Dunhill Medical Trust Ref No RPGF180666, £99,165
- ‘Oral iron, intravenous iron or discontinuation of therapy for older adults with treatment unresponsive iron deficiency anaemia- a pilot randomised controlled trial’, PK Myint, RL Soiza et al (7 co-investigators), CSO Grant Ref No HIPS/17/15, £283,555
- ‘Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older persons (SENATOR)’, EU FP7 Project Grant, D O’Mahony, RL Soiza et al (12 co-investigators), €5,938,947
- ‘Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial’ NIHR HTA Grant 10/71, MD Witham, RL Soiza et al (10 co-investigators), £1,471,735
- ‘Vitamin K supplementation to reduce falls in older people – a multicentre trial’ CSO Grant CZH/4/1100, MD Witham, M McMurdo, P Donnan, P Mc Namee, RL Soiza, V Cvoro, £213,493
- ‘Assessment of association between slow muscle fibres of calf and postural integrity between elderly fallers and non fallers using MRI techniques – a proof of concept study’ NHS Grampian Endowment Fund Research Grant 14/19, PK Myint, SR Gray, J He, RL Soiza,£11,936
- Vascular ageing and hyponatraemia, NRS Career Researcher Fellowship, £123,010
- ‘Association of White Matter Lesions with Endothelial Dysfunction and Postural Blood Pressure Instability (ENDOW Study)’ NHS Grampian Endowment Fund Research Grant, £16,000, GE Hoyle, RL Soiza, DJP Williams, DG Seymour, AD Murray
- ‘Aberdeen 1936 Birth Cohort Study: Wave 4’ Development Trust Alzheimer’s Research Fund, £41,382, AD Murray, RL Soiza, LJ Whalley
- 'Association of Postural Blood Pressure Instability with Arterial Stiffness and Endothelial Dysfunction' NHSG Endowments No. 08/26 £8,667, RL Soiza, S Saha, GE Hoyle, DJP Williams
- ‘The role of serum urate in cognitive decline’ Tenovus Scotland Project Grant G09/20 £9,456, RL Soiza, AD Murray, L Phillips, RT Staff
- ‘The association between plasma nitrite levels and degree of endothelial function measured by pulse wave analysis’ 50% NHSG Endowments No. 09/19 & 50% British Geriatrics Society SpR Start-up Grant - £13,704, RL Soiza, S Saha, DJP Williams, IJ Megson
- ‘Arginine Methylation: the missing link between vascular risk and Alzheimer’s disease severity’. NHS Grampian Endowments Research Grant 11/08, £9,084 AA Mangoni, RL Soiza, D Mowat
- ‘Can asymmetric dimethylarginine (ADMA) predict cognitive decline?’ NHS Grampian Endowments Research Grant No 11/07, £11,789, AA Mangoni, F Thies, RL Soiza, RT Staff
- Publications
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Page 3 of 7 Results 51 to 75 of 163
WHAT ARE THE ASSOCIATIONS BETWEEN RENAL BIOCHEMISTRY AND PHYSICAL PERFORMANCE IN OLDER PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE? FINDINGS FROM THE BICARB TRIAL COHORT
Age and Ageing, vol. 50, no. Supp 1, 47Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1093/ageing/afab030.08
Development of a European consensus from dentists, dental hygienists and physicians on a standard for oral health care in care‐dependent older people: an e-Delphi study
Gerodontology, vol. 38, no. 1, pp. 41-56Contributions to Journals: ArticlesEfficacy and safety of COVID-19 vaccines in older people
Age and Ageing, vol. 50, no. 2, pp. 279–283Contributions to Journals: ArticlesSCoOP Acute Hospital Outcomes Report 2018-2019: An overview of outcomes of acute geriatric medicine services in Scotland
University of Aberdeen. 40 pagesBooks and Reports: Commissioned ReportsAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
The Lancet, vol. 397, no. 10274, pp. 605-612Contributions to Journals: ArticlesBioelectrical impedance versus biochemical analysis of hydration status: predictive value for prolonged hospitalisation and poor discharge destination in older patients
Healthcare, vol. 9, no. 2, 154Contributions to Journals: ArticlesBaseline anticholinergic burden from medications predicts poorer baseline and long-term health-related quality of life in 16 675 men and women of EPIC-Norfolk prospective population-based cohort study
Pharmacoepidemiology and Drug Safety, vol. 30, no. 2, pp. 135-143Contributions to Journals: ArticlesAnticholinergic Burden Measures Predict Older People’s Physical Function and Quality of Life: A Systematic Review
Journal of the American Medical Directors Association, vol. 22, no. 1, pp. 56-64Contributions to Journals: ArticlesAnticholinergic burden measures and older people's falls risk: a systematic prognostic review.
Therapeutic Advances in Drug Safety, vol. 12, pp. 1-10Contributions to Journals: ArticlesEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19
The New England Journal of Medicine, vol. 383, no. 21, pp. 2030-2040Contributions to Journals: Articles- [ONLINE] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556338/
- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa2022926
- [ONLINE] View publication in Scopus
Global pandemic - the true incidence of adverse drug reactions
Age and Ageing, vol. 49, no. 6, pp. 934-935Contributions to Journals: EditorialsCirculating asymmetric dimethylarginine and cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort
International Journal of Geriatric Psychiatry, vol. 35, no. 10, pp. 1181-1188Contributions to Journals: ArticlesLopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
The Lancet, vol. 396, no. 10259, pp. 1345-1352Contributions to Journals: ArticlesDexamethasone in Hospitalized Patients with Covid-19: Preliminary Report
The New England Journal of MedicineContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa2021436
Prevention of Adverse Drug Reactions in Hospitalized Older Patients with Multi-morbidity and Polypharmacy: the SENATOR randomized controlled clinical trial
Age and Ageing, vol. 49, no. 4, pp. 605-614Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/ageing/afaa072
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/3/SENATOR_Trial_AgeandAgeing_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/1/Figure1_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16596/2/Figure2_AAM.pdf
- [ONLINE] View publication in Scopus
COVID-19 position statement: Presentations and management of COVID-19 in older people in acute care
Scottish Government. 14 pagesBooks and Reports: Commissioned ReportsThe prognostic value of anticholinergic burden measures in relation to mortality in older individuals: a systematic review and meta-analysis
Frontiers in Pharmacology, vol. 11, 570Contributions to Journals: ArticlesClinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial
BMC medicine , vol. 18, 91Contributions to Journals: ArticlesClinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis: The BiCARB randomised controlled trial
Health Technology Assessment, vol. 18, 91Contributions to Journals: ArticlesAssessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties
Annals of Family Medicine, vol. 18, no. 2, pp. 148-155Contributions to Journals: Articles- [ONLINE] http://www.AnnFamMed.org/content/18/2/148/suppl/DC1/
- [ONLINE] DOI: https://doi.org/10.1370/afm.2501
- [ONLINE] Deposit in University of Glasgow repository
- [ONLINE] View publication in Scopus
Non-pharmacological, non-surgical interventions for urinary incontinence in older persons: A systematic review of systematic reviews. The SENATOR project ONTOP series
Maturitas, vol. 133, pp. 42-48Contributions to Journals: ArticlesAssociation between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review
Age and Ageing, vol. 49, no. 2, pp. 184-192Contributions to Journals: Review articlesEffect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial
Journal of the American Geriatrics Society, vol. 67, no. 10, pp. 2102-2107Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jgs.16024
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13134/1/Witham_et_al_JAGS_Effect_of_vitamin_K2_VoR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Nonpharmacologic Management of Orthostatic Hypotension in Older People: A Systematic Review. The SENATOR ONTOP Series
Journal of the American Medical Directors Association, vol. 20, no. 9, pp. 1065-1073.e3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jamda.2019.03.032
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14323/1/Revision2_JAMDA_D_19_00103R2.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
The Scottish Intercollegiate Guidelines Network (SIGN) 157: Guidelines on Risk Reduction and Management of Delirium: Communication
Medicina, vol. 55, no. 8, 491Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/medicina55080491
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12723/1/Soiza_Myint_Medicina_SIGN157_VOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley