Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Senior Trial Manager

About
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address

Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENOEMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICSCLASSNIAMIFOCCUSREFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - University of Aberdeen 
  • MLitt by research 
    1994 - University of Aberdeen 
  • PhD Public Health 
    2008 - University of Aberdeen 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

Nutrition and Health

Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENOEMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

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  • After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial

    Sharp, L., Cotton, S. C., Cochran, C., Gray, N. M., Little, J., Neal, K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 11, pp. 1506-1514
    Contributions to Journals: Articles
  • Comprehensive cancer control-research & development: Knowing what we do and doing what we know

    Kerner, J. F., Cazap, E., Yach, D., Pierotti, M. A., Daidone, M. G., De Blasio, P., Geary, P., Schacter, B., Sant, M., Habbema, J. D. F., Sankaranarayanan, R., Sutcliffe, C., Sutcliffe, S., Kaijage, J. K., Scanlan, P. A., Gibson, S., Mes-Masson, A. M., Sawyer, M., Shepherd, L., Watson, P., Zanke, B., Small, I. A., Olmedo, D. B., Breitenbach, M. D., Santini, L. A., Maltoni, L. A., Ramalho, D., Ferreira, C. G., Sharp, L., Cruickshank, M., Smart, L., Harrild, K., Waugh, N., Little, J., Seth, R., Neal, K., Duncan, I., Ioka, A., Ito, Y., Sato, N., Tsukuma, H., Li, J., Zhang, B. N., Fan, J. H., Qiao, Y. L., Zhong, H. Y., Curado, M. P., Pontes, T. J., Peacock, S., Van Der Hoek, K., Hoch, J., Musa, Z., Weir, H. K., Friedman, C., German, R., Ceilleachair, A. O., Comber, H., Cotton, S., Tilson, L., Walsh, C., Usher, C., Barry, M., Chilcott, J., Tappenden, P., Whyte, S., Staines, A., Greenberg, A., Fairclough, L., Roberts, W., Masterson Tavares Pereira Ferrera, D., Fonseca, E. R., Casado, L., McBride, M. L., Goddard, K., Lorenzi, M., Spinelli, J. J., Broemeling, A. M., Glickman, V., Pritchard, S., Siegel, L., Rogers, P. C., Sheps, S., Annunziata, M. A., Giovannini, L., Bianchet, K., Muzzatti, B., Berretta, M., Lleshi, A., Tirelli, U., Sisimayi, C. N., Sarwal, K., Torrance, H., Baili, P., Amati, C., Di Salvo, F., Frazzingaro, C., Sanz, N., Micheli, A.
    Tumori, vol. 95, no. 5, pp. 610-622
    Contributions to Journals: Articles
  • Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial

    Sharp, L., Cruickshank, M., Little, J., Cotton, S., Harrild, K., Cochran, C., Duncan, I., Gray, N., Hammond, R., Smart, L., Thornton, A., Waugh, N., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2548
    Contributions to Journals: Articles
  • Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial

    Little, J., Sharp, L., Cotton, S., Cruickshank, M., Duncan, I., Harrild, K., Jenkins, D., Smart, L., Waugh, N., Cochran, C., Gray, N., Hammond, R., Neal, K., Thornton, A. J., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2546
    Contributions to Journals: Articles
  • Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study

    Whynes, D., Philips, Z., Woolley, C., Cotton, S., Cruickshank, M., Harrild, K., Little, J., Neal, K., Sharp, L., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, no. -, b2549
    Contributions to Journals: Articles
  • Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Masson, L. F., Haites, N. E., Cassidy, J.
    British Journal of Nutrition, vol. 99, no. 2, pp. 379-389
    Contributions to Journals: Articles
  • Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women

    Cotton, S. C., Sharp, L., Seth, R., Masson, L. F., Little, J., Cruickshank, M. E., Neal, K., Waugh, N. R., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 97, no. 1, pp. 133-139
    Contributions to Journals: Articles
  • Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1

    Little, J., Sharp, L., Masson, L. F., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    International Journal of Cancer, vol. 119, no. 9, pp. 2155-2164
    Contributions to Journals: Articles
  • Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Sharp, L., Cotton, S. C., Alexander, L., Williams, E., Gray, N. M., Reid, J. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Clinical Trials, vol. 3, pp. 431-442
    Contributions to Journals: Articles
  • Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design

    Cotton, S. C., Sharp, L., Little, J., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Contemporary Clinical Trials, vol. 27, no. 5, pp. 449-471
    Contributions to Journals: Articles
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