Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Senior Trial Manager

About
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address

Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENOEMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICSCLASSNIAMIFOCCUSREFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - University of Aberdeen 
  • MLitt by research 
    1994 - University of Aberdeen 
  • PhD Public Health 
    2008 - University of Aberdeen 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

Nutrition and Health

Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENOEMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

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  • Enclosing a pen with a postal questionnaire can significantly increase the response rate

    Sharp, L., Cochran, C., Cotton, S. C., Gray, N. M., Gallagher, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Clinical Epidemiology, vol. 59, no. 7, pp. 747-754
    Contributions to Journals: Articles
  • Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors

    Gray, N. M., sharp, L., Cotton, S. C., Masson, L. F., little, J., Walker, L. G., Avis, M., Philips, Z., Russell, I., Whynes, D. K., Cruickshank, M. E., Woolley, C. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 94, pp. 1253-1262
    Contributions to Journals: Articles
  • Refining the management of low-grade cervical abnormailities in the UK National Health Service and defining the potential for human papillomavirus testing: A commentary on emerging evidence

    Bentley, E., Cotton, S. C., Cruickshank, M. E., Duncan, I., Gray, N. M., Jenkins, D., little, J., Neal, K., Philips, Z., Russell, I., Seth, R., sharp, L., Waugh, N. R.
    Journal of Lower Genital Tract Disease, vol. 10, no. 1, pp. 26-38
    Contributions to Journals: Articles
  • Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) trial.

    Gray, N. M., Sharp, L., Cotton, S. C., Avis, M., Philips, Z., Russell, I., Walker, L. G., Whynes, D. K., Little, J.
    Quality of Life Research, vol. 14, no. 6, pp. 1553-1562
    Contributions to Journals: Articles
  • Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review

    Masson, L. F., Sharp, L., Cotton, S. C., Little, J.
    American Journal of Epidemiology, vol. 161, no. 10, pp. 901-915
    Contributions to Journals: Articles
  • CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review

    Sharp, L., Cardy, A. H., Cotton, S. C., Little, J.
    American Journal of Epidemiology, vol. 160, no. 8, pp. 729-740
    Contributions to Journals: Articles
  • Are lifestyle factors associated with infection with high risk human papilloma virus? results from TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Cotton, S. C., Sharp, L., Seth, R.
    Journal of Epidemiology and Community Health, vol. 58, no. Supplement II
    Contributions to Journals: Articles
  • Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population based case-control study in Scotland

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    The Journal of Nutrition, vol. 132 Supplement 11
    Contributions to Journals: Articles
  • Women’s experiences of having an abnormal smear result: qualitative analyses from TOMBOLA

    Gray, N. M., Sharp, L., Cotton, S. C., Little, J., Avis, M., Philips, Z., Walker, L. G., Duncan, I.
    Journal of Obstetrics and Gynaecology, vol. 22, pp. 107-111
    Contributions to Journals: Articles
  • Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    Journal of Epidemiology and Community Health, vol. 55, no. Supplement 1
    Contributions to Journals: Articles
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