![Professor Graeme MacLennan Professor Graeme MacLennan](/img/200x200/staffpages/uploads/sme312/Graeme_McLennan_002.jpg)
Director (CHaRT)
- About
-
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
- Research
-
Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
- Teaching
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Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
- Publications
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A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
Health Technology Assessment international 2018 Annual MeetingContributions to Conferences: AbstractsTISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones: study protocol for a randomised controlled trial
Trials, vol. 19, no. 1, pp. 1-11Contributions to Journals: ArticlesCancer and vitamin D supplementation: a systematic review and meta-analysis
The American Journal of Clinical Nutrition, vol. 107, no. 4, pp. 652-663Contributions to Journals: ArticlesInstrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery
Journal of Clinical Epidemiology, vol. 96, pp. 126-132Contributions to Journals: ArticlesThe split-plot design was useful for evaluating complex, multi-level interventions but there is need for improvement in its design and report
Journal of Clinical Epidemiology, vol. 96, pp. 120-125Contributions to Journals: ArticlesSystematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol
Trials, vol. 19, 197Contributions to Journals: ArticlesHow to resolve discrepancies when findings from randomized controlled trials and meta-analyses disagree?
33rd Annual EAU Congress 2018Contributions to Conferences: PostersMale synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial
Trials, vol. 19, pp. 1-17Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2501-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10149/1/Trials.pdf
- [ONLINE] View publication in Scopus
Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis
BMJ, vol. 359, j4849Contributions to Journals: ArticlesBayesian clinical trial designs: Another option for trauma trials?
The journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741Contributions to Journals: ArticlesTHISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial
BMC Pregnancy and Childbirth, vol. 17, 294Contributions to Journals: ArticlesThe SIMS trial: adjustable anchored single-incision mini-slings versus standard tension-free midurethral slings in the surgical management of female stress urinary incontinence. A study protocol for a pragmatic, multicentre, non-inferiority randomised controlled trial
BMJ Open, vol. 7, no. 8, pp. 1-18Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2016-015111
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9208/1/e015111.full.pdf
- [ONLINE] View publication in Scopus
Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study
Journal of Bone and Mineral Research, vol. 32, no. 6, pp. 1165-1173Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.3066
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10009/1/PRISM_EZ_.docx
Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree
European Urology, vol. 71, no. 5, pp. 811-819Contributions to Journals: ArticlesThe BJUI's clinical trials initiative
BJU International, vol. 119, no. 4, pp. 503Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1111/bju.13837
- [ONLINE] View publication in Scopus
Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)
The Lancet, vol. 389, no. 10067, pp. 381–392Contributions to Journals: ArticlesThe curious case of an internal pilot in a multicentre randomised trial-time for a rethink?
Pilot & Feasibility Studies, vol. 2, 73Contributions to Journals: ArticlesClinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study
Health Technology Assessment, vol. 20, no. 95, pp. 1-452Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta20950
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8494/1/HTA.pdf
Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?
Quality of Life Research, vol. 25, no. 12, pp. 2977-2983Contributions to Journals: ArticlesThe eEffectiveness and cost-effectiveness of Surgical Treatments for womEn with stRess urinary incontinence:: an evidence synthesis (ESTER)
Contributions to Journals: Registered ReportsBreast pumps as an incentive for breastfeeding: a mixed methods study of acceptability
Maternal and Child Nutrition, vol. 12, no. 4, pp. 726-739Contributions to Journals: ArticlesDesign and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial
BMC Psychiatry, vol. 16, pp. 1-12Contributions to Journals: ArticlesA protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials
Systematic reviews , vol. 5, 131Contributions to Journals: ArticlesAlpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review
Health Technology Assessment, vol. 20, no. 25, pp. 0-120Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.3310/hta20250
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5856/1/FullReport_hta20250.pdf
Behavioural recovery after treatment for varicose veins
British Journal of Surgery, vol. 103, no. 4, pp. 374-381Contributions to Journals: ArticlesThe ethics of future trials: qualitative analysis of physicians' decision making
Trials, vol. 17, pp. 1-8Contributions to Journals: ArticlesMindfulness-Based Stress Reduction for Veterans With PTSD
JAMA, vol. 315, no. 1, pp. 87-88Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1001/jama.2015.15170
Kurzdarstellung aktueller publikationen: Begünstigt eine muskelrelaxierende therapie den uretersteinabgang?
Nieren- und Hochdruckkrankheiten, vol. 45, no. 1, pp. 38Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial): study protocol for a randomised controlled trial
Trials, vol. 16, 600Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-015-1120-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5403/1/s13063_015_1120_4.pdf
Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study
Maternal and Child Nutrition, vol. 11, no. Supplement S2, pp. 113Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/mcn.12238
Perspectives on financial incentives to health service providers for increasing breastfeeding and smoking quit rates during pregnancy: a mixed methods study
BMJ Open, vol. 5, no. 11, e008492Contributions to Journals: ArticlesUreteric colic and clinical evidence - Authors' reply
The Lancet, vol. 386, no. 10006, pp. 1823Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(15)00764-3
Surgical management for localised penile cancer: [Cochrane Protocol]
Contributions to Journals: Registered ReportsUse of drug therapy in the management of symptomatic ureteric stones in hospitalised adults: a multicentre, placebo-controlled, randomised controlled trial and cost-effectiveness analysis of a calcium channel blocker (nifedipine) and an alpha-blocker (tamsulosin) (the SUSPEND trial)
Health Technology Assessment, vol. 19, no. 63, pp. 1-171Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta19630
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5166/1/FullReport_hta19630.pdf.crdownload
Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial
The Lancet, vol. 386, no. 9991, pp. 341-349Contributions to Journals: ArticlesAblative therapy for people with localised prostate cancer: a systematic review and economic evaluation
Health Technology Assessment, vol. 19, no. 49, pp. 1-524Contributions to Journals: ArticlesA systematic review of the use of an expertise-based randomised controlled trial design
Trials, vol. 16, 241Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-015-0739-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4683/1/Cook_2015.pdf
STOPPIT Baby Follow-Up Study: The Effect of Prophylactic Progesterone in Twin Pregnancy on Childhood Outcome
PloS ONE, vol. 10, no. 4, e0122341Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0122341
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4461/1/PLOS_0122341.pdf
Benefits of incentives for breastfeeding and smoking cessation in pregnancy (BIBS): a mixed methods study to inform trial design
Health Technology Assessment, vol. 19, no. 30, pp. 1-564Contributions to Journals: ArticlesClinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial
Health Technology Assessment, vol. 19, no. 27, pp. 1-342Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta19270
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4430/1/CLASS.pdf
Surgical management for localised penile cancer
Cochrane Database of Systematic Reviews, vol. 2015, no. 3, CD011533Contributions to Journals: Articles- [ONLINE] https://doi.org//10.1002/14651858.CD011533
- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD011533
Incentives to Promote Breastfeeding: A Systematic Review
Pediatrics, vol. 135, no. 3, pp. e687-702Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1542/peds.2014-2221
Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy: a randomized controlled trial
Surgical Endoscopy, vol. 29, no. 1, pp. 77-85Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00464-014-3416-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4491/1/SCARLESS2015.pdf
Non-compliance with randomised allocation and missing outcome data in randomised controlled trials evaluating surgical interventions: a systematic review
BMC Research Notes, vol. 8, 403Contributions to Journals: Articles- [ONLINE] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558937/
- [ONLINE] DOI: https://doi.org/10.1186/s13104-015-1364-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9530/1/Non_compliance_with_randomised_allocation_and_missing_outcome_data_in_randomised_controlled_trials_evaluating_surgical_interventions.pdf
The push me, pull you of financial incentives and health inequalities: a mixed methods study investigating smoking cessation in pregnancy and breastfeeding
European Public Health Science Conference, pp. S37Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(14)62163-2
Observational study of current use of selective decontamination of the digestive tract in UK critical care units
British Journal of Anaesthesia, vol. 113, no. 4, pp. 610-617Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/bja/aeu108
- [ONLINE] View publication in Scopus
Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis
The American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 746-755Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3945/ajcn.113.082602
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15632/1/Ford_2014.pdf
Public acceptability of financial incentives for smoking cessation in pregnancy and breastfeeding
International Journal of Behavioral Medicine, vol. 21, no. 1 Suppl., S194Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1007/s12529-014-9418-2
- [ONLINE] Abstracts from the ICBM 2014 Meeting
Public acceptability of financial incentives for smoking cessation in pregnancy and breast feeding: a survey of the British public
BMJ Open, vol. 4, no. 7, e005524Contributions to Journals: ArticlesUse of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin): study protocol for a randomized controlled trial
Trials, vol. 15, no. 1, 238Contributions to Journals: Articles- [ONLINE] http://www.trialsjournal.com/content/15/1/238
- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-15-238
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3341/3/McClinton_2014.pdf