Professor Graeme MacLennan
Director (CHaRT)
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
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Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma—study protocol
King, A. J., Fernie, G., Azuara-Blanco, A., Burr, J. M., Garway-Heath, T., Sparrow, J. M., Vale, L., Hudson, J., MacLennan, G., McDonald, A. M., Barton, K., Norrie, J.British Journal of Ophthalmology, vol. 102, no. 7, pp. 922-928Contributions to Journals: ArticlesA Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
Javanbakht, M., Moloney, E., Craig, D., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L.Health Technology Assessment international 2018 Annual MeetingContributions to Conferences: AbstractsTISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones: study protocol for a randomised controlled trial
McClinton, S., Cameron, S., Starr, K., Thomas, R., MacLennan, G., McDonald, A., Lam, T., N’Dow, J., Kilonzo, M., Pickard, R., Anson, K., Keeley, F., Burgess, N., Clark, C. T., MacLennan, S., Norrie, J., TISU Study GroupTrials, vol. 19, no. 1, pp. 1-11Contributions to Journals: ArticlesCancer and vitamin D supplementation: a systematic review and meta-analysis
Goulao, B., Stewart, F., Ford, J. A., MacLennan, G., Avenell, A.The American Journal of Clinical Nutrition, vol. 107, no. 4, pp. 652-663Contributions to Journals: ArticlesInstrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery
Cook, J. A., Maclennan, G. S., Palmer, T., Lois, N., Emsley, R.Journal of Clinical Epidemiology, vol. 96, pp. 126-132Contributions to Journals: ArticlesThe split-plot design was useful for evaluating complex, multi-level interventions but there is need for improvement in its design and report
Goulão, B., MacLennan, G., Ramsay, C.Journal of Clinical Epidemiology, vol. 96, pp. 120-125Contributions to Journals: ArticlesSystematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol
Gillies, K., Bower, P., Elliott, J., MacLennan, G., Newlands, R. S. N., Ogden, M., Treweek, S. P., Wells, M., Witham, M. D., Young, B., Francis, J. J.Trials, vol. 19, 197Contributions to Journals: ArticlesHow to resolve discrepancies when findings from randomized controlled trials and meta-analyses disagree?
Sylvester, R., Canfield, S. E., Lam, T., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernández, V., Plass, K., Van Poppel, H., N'Dow, J.33rd Annual EAU Congress 2018Contributions to Conferences: PostersMale synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial
Constable, L., Cotterill, N., Cooper, D., Glazener, C., Drake, M. J., Forrest, M., Harding, C., Kilonzo, M., MacLennan, G., McCormack, K., McDonald, A., Mundy, A., Norrie, J., Pickard, R., Ramsay, C., Smith, R., Wileman, S., Abrams, P., The MASTER Study GroupTrials, vol. 19, pp. 1-17Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2501-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10149/1/Trials.pdf
- [ONLINE] View publication in Scopus
Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis
Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.BMJ, vol. 359, j4849Contributions to Journals: ArticlesBayesian clinical trial designs: Another option for trauma trials?
Jansen, J. O., Pallmann, P., MacLennan, G., Campbell, M. K., UK-REBOA Trial InvestigatorsThe journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741Contributions to Journals: ArticlesTHISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial
Lenguerrand, E., Winter, C., Innes, K., MacLennan, G., Siassakos, D., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T., Thistle groupBMC Pregnancy and Childbirth, vol. 17, 294Contributions to Journals: ArticlesThe SIMS trial: adjustable anchored single-incision mini-slings versus standard tension-free midurethral slings in the surgical management of female stress urinary incontinence. A study protocol for a pragmatic, multicentre, non-inferiority randomised controlled trial
Abdel-Fattah, M., Maclennan, G., Kilonzo, M., Assassa, R. P., McCormack, K., Davidson, T., McDonald, A., N'Dow, J., Wardle, J., Norrie, J.BMJ Open, vol. 7, no. 8, pp. 1-18Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2016-015111
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9208/1/e015111.full.pdf
- [ONLINE] View publication in Scopus
Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study
Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H., PRISM-EZ Trial GroupJournal of Bone and Mineral Research, vol. 32, no. 6, pp. 1165-1173Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.3066
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10009/1/PRISM_EZ_.docx
Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree
Sylvester, R. J., Canfield, S. E., Lam, T. B. L., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernandez, V., Plass, K., Van Poppel, H., N'Dow, J.European Urology, vol. 71, no. 5, pp. 811-819Contributions to Journals: ArticlesThe BJUI's clinical trials initiative
Davis, J. W., MacLennan, G.BJU International, vol. 119, no. 4, pp. 503Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1111/bju.13837
- [ONLINE] View publication in Scopus
Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)
Glazener, C. M. A., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R. B., Reid, F., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study groupThe Lancet, vol. 389, no. 10067, pp. 381–392Contributions to Journals: ArticlesThe curious case of an internal pilot in a multicentre randomised trial-time for a rethink?
Cook, J. A., Beard, D. J., Cook, J. R., MacLennan, G. S.Pilot & Feasibility Studies, vol. 2, 73Contributions to Journals: ArticlesClinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study
Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K., Freeman, R., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J.Health Technology Assessment, vol. 20, no. 95, pp. 1-452Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta20950
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8494/1/HTA.pdf
Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?
Fielding, S., Ogbuagu, A., Sivasubramaniam, S., MacLennan, G., Ramsay, C. R.Quality of Life Research, vol. 25, no. 12, pp. 2977-2983Contributions to Journals: ArticlesThe eEffectiveness and cost-effectiveness of Surgical Treatments for womEn with stRess urinary incontinence:: an evidence synthesis (ESTER)
Brazzelli, M., Craig, D., Imamura, M., Wallace, S., MacLennan, G., Hudson, J., Saraswat, L., Omar, M. I., Montgomery, I.Contributions to Journals: Registered ReportsBreast pumps as an incentive for breastfeeding: a mixed methods study of acceptability
Crossland, N., Thomson, G., Morgan, H., MacLennan, G., Campbell, M., Dykes, F., Hoddinott, P.Maternal and Child Nutrition, vol. 12, no. 4, pp. 726-739Contributions to Journals: ArticlesDesign and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial
Pyle, M., Norrie, J., Schwannauer, M., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., Morrison, A. P.BMC Psychiatry, vol. 16, pp. 1-12Contributions to Journals: ArticlesA protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials
Gardner, H. R., Fraser, C., MacLennan, G., Treweek, S.Systematic reviews , vol. 5, 131Contributions to Journals: ArticlesAlpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review
Cruickshank, M., Henderson, L., MacLennan, G., Fraser, C., Campbell, M., Blackwood, B., Gordon, A., Brazzelli, M.Health Technology Assessment, vol. 20, no. 25, pp. 0-120Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.3310/hta20250
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5856/1/FullReport_hta20250.pdf
