Professor Graeme MacLennan
Director (CHaRT)
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
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The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study
Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A. K., Mannas, M., Lee, T., Marra, G., Lillaz, B., Gómez Rivas, J., olivier, J., Assmus, M., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N., Downey, A., Lal, A., Antón-Juanilla, M., Clarke, H., Lau, D., Gillams, K., Crockett, M., Nielsen, M. E., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., McGrath, J., Kasivisvanathan, V., The IDENTIFY Study GroupBJU International, vol. 128, no. 4, pp. 440-450Contributions to Journals: ArticlesWhy trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework
Newlands, R., Duncan, E., Presseau, J., Treweek, S., Lawrie, L., Bower, P., Elliott, J., Francis, J. J., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.Journal of Clinical Epidemiology, vol. 137, pp. P1-13Contributions to Journals: ArticlesSelective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care
Clarkson, J. E., Ramsay, C. R., Ricketts, D., Banerjee, A., Deery, C., Lamont, T., Boyers, D., Marshman, Z., Goulao, B., Banister, K., Conway, D., Dawett, B., Baker, S., Sherriff, A., Young, L., van der Pol, M., MacLennan, G., Floate, R., Braid, H., Fee, P., Forrest, M., Gouick, J., Mitchell, F., Gupta, E., Dakri, R., Kettle, J., McGuff, T., Dunn, K.BMC Oral Health, vol. 21, 336Contributions to Journals: ArticlesHave you had bleeding from your gums?: Self-report to Identify giNGival inflammation (The SING diagnostic accuracy and diagnostic model development study)
Goulao, B., MacLennan, G., Ramsay, C.Journal of Journal of Clinical Periodontology, vol. 48, no. 7, pp. 919-928Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jcpe.13455
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16648/1/goulao_etal_have_you_had_VOR.pdf
Shockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial
Dasgupta, R., Cameron, S., Aucott, L., MacLennan, G., Thomas, R., N'Dow, J., Norrie, J., Anson, K., Keeley Jr, F. X., MacLennan, S., Starr, K., McClinton, S., Kilonzo, M., Lam, T.European Urology, vol. 80, no. 1, pp. 46-54Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2021.02.044
The arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: The STOPPIT 2 RCT
Norman, J. E., Norrie, J., Maclennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Neilson, A. R., Mei, X. W., Smith, J. B., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., on behalf of the STOPPIT collaborative groupNIHR Health Technology Assessment programme. 94 pagesBooks and Reports: Other Reports- [ONLINE] DOI: https://doi.org/10.3310/hta25440
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17001/1/Norman_etal_HTA_The_Arabin_pessary_VOR.pdf
- [ONLINE] View publication in Scopus
Outcomes of a non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery (MASTER)
Abrams, P., Constable, L., Cooper, D., MacLennan, G., Drake, M. J., Harding, C., Mundy, A., McCormack, K., McDonald, A., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Glazener, C., MASTER trial teamEuropean Urology, vol. 79, no. 6, pp. 812-823Contributions to Journals: ArticlesTISU (Therepeutic Intervention for Stones in the Ureter): ESWL versus Ureteroscopy, a multicentre RCT
Dasgupta, R., Cameron, S., Aucott, L., Maclennan, G., Thomas, R. E., N'dow, J., Norrie, J., Anson, K., Keeley, F. X., Maclennan, S., Starr, K., Mcclinton, S.European Urology, vol. 79, no. S1, pp. S390-S390Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(21)00660-6
Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT
Booth, J., Aucott, L., Cotton, S., Davis, B., Fenocchi, L., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D., Surr, C., Treweek, S.Health technology assessment (Winchester, England), vol. 25, no. 41, pp. 1-109Contributions to Journals: ArticlesPrimary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)
King, A., Hudson, J., Fernie, G., Kernohan, A., Azuara-Blanco, A., Burr, J., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., McDonald, A., Vale, L., MacLennan, G., King, A., Agrawal, P., Stead, R., Broadway, D. C., Strouthidis, N., Chew, S., Sng, C., Toth, M., Gazzard, G., Elkarmouty, A., Nikita, E., Triolo, G., Aguilar-Munoa, S., Goyal, S., Lim, S., Sung, V., Masood, I., Wride, N., Sandhu, A., Hill, E., Sparrow, J., Grey, F., Bourne, R., Nithyanandarajah, G., Willshire, C., Bloom, P., Ahmed, F., Cordeiro, F., Crawley, L., Normando, E., Ameen, S., Tryfinopoulou, J., Porteous, A., Azuara-Blanco, A., Sidiki, S., TAGS Study GroupBMJ, vol. 373, n1014Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.n1014
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16479/1/bmj-373-bmj-n1014.pdf
Equity of access to critical care services in Scotland: A Bayesian spatial analysis
Emerson, P., Green, D. R., Stott, S., Maclennan, G., Campbell, M. K., Jansen, J. O.Journal of the Intensive Care Society, vol. 22, no. 2, pp. 127-135Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1751143720914462
- [ONLINE] View publication in Scopus
Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis
Norman, J. E., Norrie, J., MacLennan, G., Cooper, D., Whyte, S., Chowdhry, S., Cunningham-Burley, S., Mei, X. W., Smith, J. B. E., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J., STOPPIT-2 collaborative groupPLoS Medicine, vol. 18, no. 3, e1003506Contributions to Journals: ArticlesProtocol for a randomised controlled trial comparing laparoscopic cholecystectomy with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones (C-Gall trial)
Ahmed, I., Innes, K., Brazzelli, M., Gillies, K., Newlands, R., Avenell, A., Hernández, R., Blazeby, J., Croal, B., Hudson, J., MacLennan, G., McCormack, K., McDonald, A., Murchie, P., Ramsay, C.BMJ Open, vol. 11, no. 3, e039781Contributions to Journals: Articles- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/33766835/
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2020-039781
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16202/1/Ahmed_etal_Protocol_for_randomised_VOR.pdf
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/protocol-for-a-randomised-controlled-trial-comparing-laparoscopic-cholecystectomy-with-observationconservative-management-for-preventing-recurrent-symptoms-and-complications-in-adults-with-uncomplica(a66000bc-ddf4-4d6b-9167-7efd1556eace).html
Survey on ureTEric draiNage post uncomplicaTed ureteroscopy (STENT)
Bhatt, N. R., MacKenzie, K., Shah, T. T., Gallagher, K., Clement, K., Cambridge, W. A., Kulkarni, M., MacLennan, G., Manecksha, R. P., Wiseman, O. J., Mcclinton, S., Smith, D., Kasivisvanathan, V.BJUI Compass, vol. 2, no. 2, pp. 115-125Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bco2.48
- [ONLINE] View publication in Scopus
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
Morrison, A. P., Pyle, M., Byrne, R., Broome, M., Freeman, D., Johns, L., James, A., Husain, N., Whale, R., MacLennan, G., Norrie, J., Hudson, J., Peters, S., Davies, L., Bowe, S., Smith, J., Shiers, D., Joyce, E., Jones, W., Hollis, C., Maughan, D.Health technology assessment (Winchester, England), vol. 25, no. 4, pp. 1-124Contributions to Journals: ArticlesOpen urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT
Pickard, R., Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Breckons, M., Vale, L., Whybrow, P., Rapley, T., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., McColl, E., Andrich, D., Barclay, S., Cook, J., Mundy, A., N'Dow, J., Payne, S., Watkin, N.Contributions to Journals: Registered Reports- [ONLINE] DOI: https://doi.org/10.3310/hta24610
Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)
Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Cook, J., McColl, E., Breckons, M., Vale, L., Whybrow, P., Rapley, T., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., Andrich, D., Barclay, S., Mundy, A., N'Dow, J., Payne, S., Watkin, N., Pickard, R.European Urology, vol. 78, no. 4, pp. 572-580Contributions to Journals: ArticlesAntipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
Morrison, A. P., Pyle, M., Maughan, D., Johns, L., Freeman, D., Broome, M. R., Husain, N., Fowler, D., Hudson, J., MacLennan, G., Norrie, J., Shiers, D., Hollis, C., James, A., MAPS groupThe lancet. Psychiatry, vol. 7, no. 9, pp. 788-800Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S2215-0366(20)30248-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14938/1/PIIS2215036620302480.pdf
- [ONLINE] View publication in Scopus
Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)
Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., Reid, F. M., PROSPECT study groupBJOG-An International Journal of Obstetrics and Gynaecology, vol. 127, no. 8, pp. 1002-1013Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.16197
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14488/1/Glazener_etal_BJOG_Mesh_inlay_VOR.pdf
- [ONLINE] View publication in Scopus
The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: the percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole kidney stones randomised controlled trial (PUrE RCT) protocol
McClinton, S., Starr, K., Thomas, R., MacLennan, G., Lam, T., Hernandez, R., Pickard, R., Anson, K., Clark, T., MacLennan, S., Thomas, D., Smith, D., Turney, B., McDonald, A., Cameron, S., Wiseman, O.Trials, vol. 21, 479Contributions to Journals: ArticlesTotal versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
Beard, D. J., Davies, L. J., Cook, J. A., MacLennan, G., Price, A., Kent, S., Hudson, J., Carr, A., Leal, J., Campbell, H., Fitzpatrick, R., Arden, N., Murray, D., Campbell, M. K.Health technology assessment (Winchester, England), vol. 24, no. 20, pp. 1-98Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta24200
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14438/1/3032379.pdf
- [ONLINE] View publication in Scopus
Baseline Characteristics of Participants in the Treatment of Advanced Glaucoma Study: A Multicenter Randomized Controlled Trial
King, A. J., Hudson, J., Fernie, G., Burr, J., Azuara-Blanco, A., Sparrow, J. M., Barton, K., Garway-Heath, D., Kernohan, A., MacLennan, G., TAGS Research GroupAmerican Journal of Ophthalmology, vol. 213, pp. 186-194Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ajo.2020.01.026
- [ONLINE] View publication in Scopus
Surgical treatments for women with stress urinary incontinence: a systematic review of economic evidence
Javanbakht, M., Moloney, E., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., MacLennan, G., Vale, L., Craig, D.Systematic reviews , vol. 9, 85Contributions to Journals: ArticlesEffect of hands-on interprofessional simulation training for local emergencies in Scotland: the THISTLE stepped-wedge design randomised controlled trial
Lenguerrand, E., Winter, C., Siassakos, D., MacLennan, G., Innes, K., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T.BMJ Quality & Safety, vol. 29, no. 2, pp. 122-134Contributions to Journals: ArticlesEarly signs monitoring to prevent relapse in psychosis and promote well-being, engagement, and recovery: Protocol for a feasibility cluster randomized controlled trial harnessing mobile phone technology blended with peer support
Gumley, A., Bradstreet, S., Ainsworth, J., Allan, S., Alvarez-Jimenez, M., Beattie, L., Bell, I., Birchwood, M., Briggs, A., Bucci, S., Castagnini, E., Clark, A., Cotton, S. M., Engel, L., French, P., Lederman, R., Lewis, S., Machin, M., MacLennan, G., Matrunola, C., McLeod, H., McMeekin, N., Mihalopoulos, C., Morton, E., Norrie, J., Reilly, F., Schwannauer, M., Singh, S. P., Smith, L., Sundram, S., Thomson, D., Thompson, A., Whitehill, H., Wilson-Kay, A., Williams, C., Yung, A., Farhall, J., Gleeson, J.JMIR Research Protocols, vol. 9, no. 1, pp. e15058Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2196/15058
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14678/1/document.pdf
- [ONLINE] View publication in Scopus
