I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
PUrE RCT 1: Clinical and cost-effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones ≤10 mm
Wiseman, O., Smith, R., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
European Urology, vol. 85, no. Supplement 1, pp. S529
PUrE RCT 2: Clinical and cost-effectiveness of FURS and percutaneous nephrolithotomy for lower pole stones 10-25mm
Smith, R., Wiseman, O., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
European Urology, vol. 85, no. Supplement 1, pp. S537
Reply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4
Heer, R., Tan, W. S., Gravestock, P., Vadiveloo, T., Lewis, R., Penegar, S., Vale, L., MacLennan, G., Hall, E., PHOTO Trial Team
SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial
Long, M. B., Abo-Leyah, H., Giam, Y. H., Vadiveloo, T., Hull, R. C., Keir, H. R., Pembridge, T., De Lima, D. A., Delgado, L., Inglis, S. K., Hughes, C., Gilmour, A., Gierlinski, M., New, B. J., Maclennan, G., Dinkova-Kostova, A. T., Chalmers, J. D.
How surgical Trainee Research Collaboratives achieve success: a mixed methods study to develop trainee engagement strategies
Clement, C., Coulman, K., Heywood, N., Pinkney, T., Blazeby, J., Blencowe, N. S., Cook, J. A., Bulbulia, R., Arenas-Pinto, A., Snowdon, C., Hilton, Z., Magill, L., MacLennan, G., Glasbey, J., Nepogodiev, D., Hardy, V., Lane, J. A.
Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial
Ahmed, I., Hudson, J., Innes, K., Hernández, R., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
Cost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases
Chong, H. Y., McNamee, P., Bachmair, E., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., Macfarlane, G., Basu, N., LIFT study group
Development of an intervention to manage benzodiazepine dependence and high-risk use in the context of escalating drug related deaths in Scotland: an application of the MRC framework
Berry, K., Matheson, C., Schofield, J., Dumbrell, J., Parkes, T., Hill, D., Kilonzo, M., MacLennan, G., Stewart, D., Ritchie, T., Turner, M.
BMC Health Services Research, vol. 23, no. 1, 1205
