I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial
Hernández, R. A., Ahmed, I., Edwards, K., Hudson, J., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B. L., MacLennan, G., Murchie, P., Ramsay, C.
British Journal of Surgery, vol. 112, no. 1, znae293
A feasibility randomized controlled trial of an individually delivered, peer support intervention to reduce the impact of psychosis stigma and discrimination for people with psychosis: the let's talk study
Pyle, M., Corrigan, P. W., Wood, L., Pilling, S., Murphy, E., Macafee, G., Kelly, K., Byrne, R., Dunbar, E., Jones, E., Hudson, J., Jones, W., Hazzard, R., Larson, J. E., MacLennan, G., Swingler, J., Peters, S., Morrison, A. P., Let's Talk Research Group
A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease
Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Wu, O., Lipworth, B. J.
Health Technology Assessment
Contributions to Journals: Articles
CATHETER II: a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Dimitropoulos, K., Evans, S., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A., Cotton, S., Norrie, J., MacLennan, G.
Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT
Thompson, L., Tanner, J., Breckons, M., Young, N., Ternent, L., Vadiveloo, T., Wilson, P., Wight, D., Marryat, L., McGowan, I., MacLennan, G., MacBeth, A., McTaggart, J., Allison, T., Norrie, J.
Which glaucoma patients should be monitored at home and exploration of clinician perceptions on home monitoring? a survey of glaucoma specialists in the UK
Alagappan, U., Stewart, C., Azuara-Blanco, A., King, A. J., Tatham, A., Hernández, R., MacLennan, G., Shotton, D., Forrest, M., Gillies, K.
RCT comparing the clinical and cost effectiveness of various catheter washout policies
Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G.
The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT
Jansen, J. O., Hudson, J., Kennedy, C., Cochran, C., Maclennan, G., Gillies, K., Lendrum, R., Sadek, S., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Cotton, S., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., UK-REBOA Study Group
