I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
Cook, J. A., Julious, S. A., Sones, W., Hampson, L. V., Hewitt, C., Berlin, J. A., Ashby, D., Emsley, R., Fergusson, D. A., Walters, S. J., Wilson, E. C., Maclennan, G., Stallard, N., Rothwell, J. C., Bland, M., Brown, L., Ramsay, C. R., Cook, A., Armstrong, D., Altman, D., Vale, L. D.
COMPARISON OF NINE SURGICAL TREATMENTS FOR WOMEN WITH STRESS URINARY INCONTINENCE: A COST-EFFECTIVENESS AND VALUE OF INFORMATION ANALYSIS
Javanbakht, M., Moloney, E., Brazzelli, M., Wallace, S. A., Ternent, L., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L., Craig, D.
11th Annual European UroGynaecological Association Congress
A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
Javanbakht, M., Moloney, E., Craig, D., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L.
ICS 2018
Contributions to Conferences: Abstracts
Partial factorial trials: comparing methods for statistical analysis and economic evaluation
Dakin, H. A., Gray, A. M., MacLennan, G. S., Morris, R. W., Murray, D. W.
Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S. E., French, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R. E., Davies, L., Kingdon, D., FOCUS trial group
The lancet. Psychiatry, vol. 5, no. 8, pp. 633-643
Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma—study protocol
King, A. J., Fernie, G., Azuara-Blanco, A., Burr, J. M., Garway-Heath, T., Sparrow, J. M., Vale, L., Hudson, J., MacLennan, G., McDonald, A. M., Barton, K., Norrie, J.
British Journal of Ophthalmology, vol. 102, no. 7, pp. 922-928
A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
Javanbakht, M., Moloney, E., Craig, D., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L.
Health Technology Assessment international 2018 Annual Meeting
Contributions to Conferences: Abstracts
TISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones: study protocol for a randomised controlled trial
McClinton, S., Cameron, S., Starr, K., Thomas, R., MacLennan, G., McDonald, A., Lam, T., N’Dow, J., Kilonzo, M., Pickard, R., Anson, K., Keeley, F., Burgess, N., Clark, C. T., MacLennan, S., Norrie, J., TISU Study Group
