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Health Economics Research Unit (HERU)

Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

    Jansen, J. O., Hudson, J., Cochran, C., MacLennan, G., Lendrum, R., Sadek, S., Gillies, K., Cotton, S., Kennedy, C., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., Aylwin, C., Bew, D., Brooks, A., Chinery, J., Cowlam, T., Frith, D., George, A., Hudson, A., Johnstone, P., Mahmood, A., Novak, A., O'Meara, M., Reid, S., Sattout, A., Smith, C., Stansfield, T., Thompson, J., UK-REBOA Study Group
    JAMA, vol. 330, no. 19, pp. 1862-1871
    Contributions to Journals: Articles

  • Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma

    Kernohan, A., Homer, T., Shabaninejad, H., King, A. J., Hudson, J., Fernie, G., Azuara-Blanco, A., Burr, J., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., Maclennan, G., Vale, L.
    British Journal of Ophthalmology, vol. 107, no. 10, pp. 1452-1457
    Contributions to Journals: Articles

  • Patient preferences for stress urinary incontinence treatments: a discrete choice experiment

    Boyers, D., Kilonzo, M., Davidson, T., Cooper, D., Wardle, J., Bhal, K., N’Dow, J., MacLennan, G., Norrie, J., Abdel-Fattah, M.
    BMJ Open, vol. 13, no. 8, pp. e066157
    Contributions to Journals: Articles

  • PROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse

    Reid, F. M., Aucott, L., Glazener, C. M., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R., Hagen, S., Kilonzo, M., Boyers, D., MacLennan, G., Norrie, J., Breeman, S., PROSPECT study group
    International Urogynecology Journal, vol. 34, pp. 67-78
    Contributions to Journals: Articles

  • Cost utility analysis of shockwave lithotripsy versus ureteroscopic stone treatment in adults

    Kilonzo, M. M., Dasgupta, R., Thomas, R., Aucott, L., MacLennan, S., Lam, T., Anson, K., Cameron, S., Starr, K., Burgess, N., Keeley, F. X., Clark, C. T., N’Dow, J., MacLennan, G., McClinton, S.
    BJU International, vol. 131, no. 2, pp. 253-261
    Contributions to Journals: Articles

  • Correction to: Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study (Pilot and Feasibility Studies, (2022), 8, 1, (77), 10.1186/s40814-022-01029-9)

    Clarkson, J. E., Ramsay, C. R., Mannocci, F., Jarad, F., Albadri, S., Ricketts, D., Tait, C., Banerjee, A., Deery, C., Boyers, D., Marshman, Z., Goulao, B., Hamilton, A. R., Banister, K., Bell, R., Brown, L., Conway, D. I., Donaldson, P., Duncan, A., Dunn, K., Fee, P., Forrest, M., Glenny, A. M., Gouick, J., Gupta, E., Jacobsen, E., Kettle, J., MacLennan, G., Macpherson, L., McGuff, T., Mitchell, F., van der Pol, M., Moazzez, R., Roberston, D., Wojewodka, G., Young, L., Lamont, T.
    Pilot and Feasibility Studies, vol. 8, 82
    Contributions to Journals: Comments and Debates

  • Single-incision mini-slings versus standard synthetic mid-urethral slings for surgical treatment of stress urinary incontinence in women: The SIMS RCT

    Abdel-Fattah, M., Cooper, D., Davidson, T., Kilonzo, M., Boyers, D., Bhal, K., McDonald, A., Wardle, J., N'Dow, J., MacLennan, G., Norrie, J.
    Health technology assessment (Winchester, England), vol. 26, no. 47, pp. 1-190
    Contributions to Journals: Articles

  • Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: results from the IDENTIFY Collaborative Study

    Khadhouri, S., Gallagher, K. M., Shah, T. T., Gao, C., Moore, S., Zimmermann, E. F., Edison, E., Jefferies, M., Nambiar, A., Anbarasan, T., Mannas, M. P., Lee, T., Marra, G., Gómez Rivas, J., Marcq, G., Assmus, M. A., Uçar, T., Claps, F., Boltri, M., La Montagna, G., Burnhope, T., Nkwam, N., Austin, T., Boxall, N. E., Downey, A. P., Sukhu, T. A., Antón-Juanilla, M., Rai, S., Chin, Y., Moore, M., Drake, T., Green, J. S., Goulao, B., MacLennan, G., Nielsen, M., McGrath, J. S., Kasivisvanathan, V., Chaudry, A., Sharma, A., Bennett, A., MacKay, A., Gordon, D., Jones, J., Brown, K., Osei-Bonsu, P. K., Smith, P., Ellis, R., Hawkins, R., Khan, S., The IDENTIFY Study Group, MacKenzie, K.
    European Urology Focus, vol. 8, no. 6, pp. 1673-1682
    Contributions to Journals: Articles

  • Photodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT

    Heer, R., Lewis, R., Duncan, A., Penegar, S., Vadiveloo, T., Clark, E., Yu, G., Mariappan, P., Cresswell, J., McGrath, J., N'Dow, J., Nabi, G., Mostafid, H., Kelly, J., Ramsay, C., Lazarowicz, H., Allan, A., Breckons, M., Campbell, K., Campbell, L., Feber, A., McDonald, A., Norrie, J., Orozco-Leal, G., Rice, S., Tandogdu, Z., Taylor, E., Wilson, L., Vale, L., MacLennan, G., Hall, E.
    Health technology assessment (Winchester, England), vol. 26, no. 40, pp. 1-144
    Contributions to Journals: Articles

  • A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer

    Heer, R., Lewis, R., Vadiveloo, T., Yu, G., Mariappan, P., Cresswell, J., McGrath, J., Nabi, G., Mostafid, H., Lazarowicz, H., Kelly, J., Duncan, A., Penegar, S., Breckons, M., Wilson, L., Clark, E., Feber, A., Orozco-Leal, G., Tandogdu, Z., Taylor, E., N'Dow, J., Norrie, J., Ramsay, C., Rice, S., Vale, L., MacLennan, G., Hall, E.
    NEJM evidence, vol. 1, no. 10, EVIDoa2200092
    Contributions to Journals: Articles

  • The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial

    Murchie, P., Constable, L., Hall, S., Brant, W., Allan, J., Johnston, M., Masthoff, J., Lee, A., Treweek, S., Ayansina, D., Proby, C., Rahman, K., Walter, F., Burrows, N., Durrani, A., Maclennan, G.
    JMIR cancer, vol. 8, no. 3, e37539
    Contributions to Journals: Articles

  • Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study

    Abdel-fattah, M., Johnson, D., Constable, L., Thomas, R., Cotton, S., Tripathee, S., Cooper, D., Boran, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, S., Murchie, P., Myint, P., N’Dow, J., Norrie, J., Omar, M. I., Paterson, C., Scotland, G., Thiruchelvam, N., MacLennan, G.
    Trials, vol. 23, no. 1, 630
    Contributions to Journals: Articles

  • Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases: a multi-centre randomised controlled parallel open-label group trial (LIFT)

    Bachmair, E., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., McNamee, P., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., LIFT study group, Macfarlane, G., Basu, N.
    The Lancet Rheumatology, vol. 4, no. 8, pp. e534-e545
    Contributions to Journals: Articles

  • Synthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT

    Constable, L., Abrams, P., Cooper, D., Kilonzo, M., Cotterill, N., Harding, C. K., Drake, M. J., Pardoe, M. N., McDonald, A., Smith, R., Norrie, J., McCormack, K., Ramsay, C., Uren, A., Mundy, T., Glazener, C., MacLennan, G.
    Health Technology Assessment, vol. 26, no. 36, 184
    Contributions to Journals: Articles

  • Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

    Macaulay, L., O’Dolan, C., Avenell, A., Carroll, P., Cotton, S., Dombrowski, S., Elders, A., Goulao, B., Gray, C., Harris, F. M., Hunt, K., Kee, F., MacLennan, G., McDonald, M. D., McKinley, M., Skinner, R., Torrens, C., Tod, M., Turner, K., van der Pol, M., Hoddinott, P.
    Trials, vol. 23, no. 1, 582
    Contributions to Journals: Articles

  • Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongste, J. C., Pijnenburg, M. W., Thomas, M., Price, D.
    The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592
    Contributions to Journals: Articles

  • Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation, vol. 9, no. 4
    Contributions to Journals: Articles

  • The EMPOWER blended digital intervention for relapse prevention in schizophrenia: a feasibility cluster randomised controlled trial in Scotland and Australia

    Gumley, A. I., Bradstreet, S., Ainsworth, J., Allan, S., Alvarez-Jimenez, M., Aucott, L., Birchwood, M., Briggs, A., Bucci, S., Cotton, S. M., Engel, L., French, P., Lederman, R., Lewis, S., Machin, M., MacLennan, G., McLeod, H., McMeekin, N., Mihalopoulos, C., Morton, E., Norrie, J., Schwannauer, M., Singh, S. P., Sundram, S., Thompson, A., Williams, C., Yung, A. R., Farhall, J., Gleeson, J.
    The Lancet Psychiatry, vol. 9, no. 6, pp. 477-486
    Contributions to Journals: Articles

  • Visualising harms in publications of randomised controlled trials: consensus and recommendations

    Phillips, R., Cro, S., Wheeler, G., Bond, S., Morris, T. P., Creanor, S., Hewitt, C., Love, S., Lopes, A., Schlackow, I., Gamble, C., MacLennan, G., Habron, C., Gordon, A. C., Vergis, N., Li, T., Qureshi, R., Everett, C. C., Holmes, J., Kirkham, A., Peckitt, C., Pirrie, S., Ahmed, N., Collett, L., Cornelius, V.
    BMJ (Clinical research ed.), vol. 377, e068983
    Contributions to Journals: Articles

  • The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)

    Jansen, J. O., Cochran, C., Boyers, D., Gillies, K., Lendrum, R., Sadek, S., Lecky, F., MacLennan, G., Campbell, M. K., UK-REBOA Trial grantholders
    Trials, vol. 23, no. 1, 384
    Contributions to Journals: Articles

  • Digital smartphone intervention to recognise and manage early warning signs in schizophrenia to prevent relapse: the EMPOWER feasibility cluster RCT

    Gumley, A. I., Bradstreet, S., Ainsworth, J., Allan, S., Alvarez-Jimenez, M., Birchwood, M., Briggs, A., Bucci, S., Cotton, S., Engel, L., French, P., Lederman, R., Lewis, S., Machin, M., Maclennan, G., McLeod, H., McMeekin, N., Mihalopoulos, C., Morton, E., Norrie, J., Reilly, F., Schwannauer, M., Singh, S. P., Sundram, S., Thompson, A., Williams, C., Yung, A., Aucott, L., Farhall, J., Gleeson, J.
    Health Technology Assessment, vol. 26, no. 27, pp. v-122
    Contributions to Journals: Articles

  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease, vol. 24, no. 4, pp. 411-421
    Contributions to Journals: Articles

  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles

  • The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials

    Newlands, R., Duncan, E., Treweek, S., Elliott, J., Presseau, J., Bower, P., MacLennan, G., Ogden, M., Wells, M., Witham, M. D., Young, B., Gillies, K.
    Trials, vol. 23, no. 1, 268
    Contributions to Journals: Articles

  • Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study

    Hamilton, A., Clarkson, J. E., Ramsay, C. R., Mannocci, F., Jarad, F., Albadri, S., Ricketts, D., Tait, C., Banerjee, A., Deery, C., Boyers, D., Marshman, Z., Goulao, B., Hamilton, A. R., Banister, K., Bell, R., Brown, L., Conway, D. I., Donaldson, P., Duncan, A., Dunn, K., Fee, P., Forrest, M., Glenny, A. M., Gouick, J., Gupta, E., Jacobsen, E., Kettle, J., MacLennan, G., Macpherson, L., McGuff, T., Mitchell, F., van der Pol, M., Moazzez, R., Roberston, D., Wojewodka, G., Young, L., Lamont, T.
    Pilot and Feasibility Studies, vol. 8, 77
    Contributions to Journals: Articles
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